MICAL1 and RAB10

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MICAL1	RAB10
Description		microtubule associated monooxygenase, calponin and LIM domain containing 1	RAB10, member RAS oncogene family
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Intermediate Filament Actin Filament Plasma Membrane Cilium Endosome Membrane Actin Cytoskeleton Membrane Midbody Ciliary Basal Body Intercellular Bridge Plasma Membrane Bounded Cell Projection Hippocampal Mossy Fiber Expansion	Golgi Membrane Exocyst Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cilium Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Insulin-responsive Compartment Cell Projection Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Exocytic Vesicle Endoplasmic Reticulum Tubular Network Secretory Vesicle
	Molecular Function	Actin Binding Monooxygenase Activity Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen SH3 Domain Binding Protein Kinase Binding Small GTPase Binding Metal Ion Binding Actin Filament Binding FAD Binding F-actin Monooxygenase Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Cytoskeleton Organization Signal Transduction Sulfur Oxidation Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Actin Filament Bundle Assembly Regulation Of Regulated Secretory Pathway	Exocytosis Golgi To Plasma Membrane Transport Axonogenesis Protein Transport Vesicle-mediated Transport Endosomal Transport Antigen Processing And Presentation Polarized Epithelial Cell Differentiation Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Regulated Exocytosis Establishment Of Neuroblast Polarity Endoplasmic Reticulum Tubular Network Organization Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Cell-cell Adhesion Protein Localization To Basolateral Plasma Membrane
Pathways		Factors involved in megakaryocyte development and platelet production	Translocation of SLC2A4 (GLUT4) to the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Depression in smokers ( 30219690) Height ( 28552196)	Apolipoprotein B levels ( 32203549) Glycated hemoglobin levels ( 34059833) Immune response to smallpox vaccine (IL-6) ( 22542470) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Metabolite levels (HVA/MHPG ratio) ( 23319000) Platelet distribution width ( 32888494)
Interacting Genes		16 interacting genes: ABL1 CRK EHD1 GADD45A GRB2 GSK3B NEDD9 PIK3R3 PTK2 RAB10 RAB1A RAB1B RPS6KA6 SRC TAB1 VIM	10 interacting genes: APP CEBPA ENOPH1 EVI5L MICAL1 MTNR1A PPBP RABIF RIMS1 SEPTIN9
Entrez ID		64780	10890
HPRD ID		06183	06692
Ensembl ID		ENSG00000135596	ENSG00000084733
Uniprot IDs		Q8TDZ2	P61026
PDB IDs		1WYL 2CO8 2DK9 5LE0 5LPN 6KU0 8HLO 8Y6K 9EWY	5LPN 5SZJ
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell-substrate Adhesion SH2 Domain Binding Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Organelle Organization Regulation Of Substrate Adhesion-dependent Cell Spreading Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Cell Migration Scaffold Protein Binding Positive Regulation Of Cell Motility Negative Regulation Of Anoikis ERBB Signaling Pathway Positive Regulation Of Locomotion Nucleotide Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of MAPK Cascade Establishment Of Cell Polarity Regulation Of Cell Projection Organization Protein Domain Specific Binding Regulation Of Anoikis Integrin-mediated Signaling Pathway Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Cellular Response To Fluid Shear Stress Fc-gamma Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Organelle Organization Epithelial Cell Development Regulation Of Cytoskeleton Organization Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Metabolic Process Developmental Process Response To Fluid Shear Stress Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Mononuclear Cell Migration
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