MAPK4 and GAB2

Number of citations: 0 (PubMedID 12008033)
Data Source: HPRD (in vitro)

		MAPK4	GAB2
Name		mitogen-activated protein kinase 4	GRB2 associated binding protein 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytosol Plasma Membrane Membrane Membrane Raft
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Intracellular Signal Transduction	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Osteoclast Differentiation Positive Regulation Of Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		MAPK6/MAPK4 signaling	PI3K Cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Constitutive Signaling by Aberrant PI3K in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Interleukin-15 signaling Interleukin receptor SHC signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants
Drugs		Acetylsalicylic acid Minocycline Colforsin Fostamatinib	None
GWAS		Diastolic blood pressure ( 28135244 ) Diisocyanate-induced asthma ( 25918132 ) Granulocyte count ( 27863252 ) Large HDL particle concentration ( 29084231 ) Monocyte count ( 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Normal facial asymmetry (angle of surface orientation score) ( 30631343 ) Phospholipid levels in large HDL ( 29084231 ) Phospholipid levels in medium HDL ( 29084231 ) Pulse pressure ( 27841878 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Systolic blood pressure ( 30578418 27841878 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 )	Alanine aminotransferase levels ( 33547301 ) Alzheimer's disease (late onset) ( 17553421 ) Alzheimer's disease (survival time) ( 25649651 ) Aspartate aminotransferase levels ( 33547301 ) Blond vs. brown/black hair color ( 30531825 ) Body mass index ( 28892062 ) Brown vs. black hair color ( 30531825 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Creatine kinase levels ( 29403010 ) Creatinine levels ( 29403010 ) Diastolic blood pressure ( 30224653 ) Estimated glomerular filtration rate ( 31152163 30604766 ) Glomerular filtration rate ( 29403010 ) Hair color ( 29662168 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Intraocular pressure ( 29785010 ) Lactate dehydrogenase levels ( 29403010 ) LDL cholesterol ( 30275531 ) Lipid traits (pleiotropy) (HIPO component 2) ( 30289880 ) Menarche (age at onset) ( 25231870 21102462 ) Platelet distribution width ( 32888494 ) Testicular germ cell tumor ( 28604732 28604728 26503584 ) Total cholesterol levels ( 30275531 ) Tourette syndrome ( 30818990 ) Triglyceride levels ( 32203549 ) Triglycerides ( 30275531 )
Novel Interactors		None recorded	1 novel interactors: TENM4
Interacting Genes		7 interacting genes: AKT1 CALML3 CCND3 CRK GAB1 GAB2 MAPKAPK5	30 interacting genes: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 MYO15B NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SNCA SRC SYK TNFRSF11A ZAP70
Entrez ID		5596	9846
HPRD ID		01497	05866
Ensembl ID		ENSG00000141639	ENSG00000033327
Uniprot IDs		B4DEW2 K7ELV1 P31152	Q9UQC2
PDB IDs		Not available	2VWF 2W0Z 5EWZ 5EXA 6Y3R 6Y3S 6ZVB 6ZVC 6ZVD 6ZVE
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol-3,4-bisphosphate Binding Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Phosphatidylinositol-3,4,5-trisphosphate Binding Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition ERBB Signaling Pathway Regulation Of Lymphocyte Migration Regulation Of TRNA Methylation Insulin Receptor Signaling Pathway Signaling Adaptor Activity Negative Regulation Of TOR Signaling Positive Regulation Of Protein Localization To Membrane Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endothelial Cell Migration Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Response To Insulin-like Growth Factor Stimulus Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Mitotic Cell Cycle Phase Transition Mammalian Oogenesis Stage Protein Autophosphorylation Kinase Binding Positive Regulation Of Cell Migration TRNA (guanine-N7)-methylation Positive Regulation Of Cell Motility Positive Regulation Of Endothelial Cell Migration Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Signal Transduction By P53 Class Mediator Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex Helper T Cell Diapedesis Cerebellar Neuron Development Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Septin Cytoskeleton Response To Calcium Ion Positive Regulation Of Locomotion Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane	Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of MAPK Cascade Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune Response ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signaling Cassette Leukocyte Activation Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Activation T Cell Costimulation Immune System Process Cell-cell Junction Regulation Of T Cell Activation Cell Activation Regulation Of Lymphocyte Activation Regulation Of Defense Response Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lymphocyte Activation Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of T Cell Activation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Negative Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Cytokine-mediated Signaling Pathway