MAPK4 and CALML3

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		MAPK4	CALML3
Name		mitogen-activated protein kinase 4	calmodulin like 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Centrosome Synaptic Vesicle Membrane Myelin Sheath Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Intracellular Signal Transduction	Detection Of Calcium Ion Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcineurin-mediated Signaling
Pathways		MAPK6/MAPK4 signaling	None
Drugs		Acetylsalicylic acid Minocycline Colforsin Fostamatinib	None
GWAS		Diastolic blood pressure ( 28135244 ) Diisocyanate-induced asthma ( 25918132 ) Granulocyte count ( 27863252 ) Large HDL particle concentration ( 29084231 ) Monocyte count ( 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Normal facial asymmetry (angle of surface orientation score) ( 30631343 ) Phospholipid levels in large HDL ( 29084231 ) Phospholipid levels in medium HDL ( 29084231 ) Pulse pressure ( 27841878 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Systolic blood pressure ( 30578418 27841878 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 )	Fasting insulin ( 34074324 )
Novel Interactors		None recorded	1 novel interactors: IL2RA
Interacting Genes		7 interacting genes: AKT1 CALML3 CCND3 CRK GAB1 GAB2 MAPKAPK5	9 interacting genes: BHLHE40 C11orf65 IQCB1 IQCN ISOC2 MAPK4 MFHAS1 MYO10 TERF2IP
Entrez ID		5596	810
HPRD ID		01497	00244
Ensembl ID		ENSG00000141639	ENSG00000178363
Uniprot IDs		B4DEW2 K7ELV1 P31152	P27482
PDB IDs		Not available	1GGZ
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol-3,4-bisphosphate Binding Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Phosphatidylinositol-3,4,5-trisphosphate Binding Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition ERBB Signaling Pathway Regulation Of Lymphocyte Migration Regulation Of TRNA Methylation Insulin Receptor Signaling Pathway Signaling Adaptor Activity Negative Regulation Of TOR Signaling Positive Regulation Of Protein Localization To Membrane Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endothelial Cell Migration Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Response To Insulin-like Growth Factor Stimulus Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Mitotic Cell Cycle Phase Transition Mammalian Oogenesis Stage Protein Autophosphorylation Kinase Binding Positive Regulation Of Cell Migration TRNA (guanine-N7)-methylation Positive Regulation Of Cell Motility Positive Regulation Of Endothelial Cell Migration Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Signal Transduction By P53 Class Mediator Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex Helper T Cell Diapedesis Cerebellar Neuron Development Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Septin Cytoskeleton Response To Calcium Ion Positive Regulation Of Locomotion Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane	None