TMEM139 and SFTPC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM139	SFTPC
Description		transmembrane protein 139	surfactant protein C
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process		Respiratory Gaseous Exchange By Respiratory System
Pathways			Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs
Diseases			Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS			Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)
Interacting Genes		41 interacting genes: ABHD16A AGTRAP APOL2 ATP6V0C BCL2L2 CD151 CDS2 CLN6 CMTM5 CTSA CXCL16 CYB5B FAXDC2 KCNK1 MALL MARCHF5 MIP NAPB NEDD4 NINJ2 NKG7 NSG1 PLPP4 PMP22 SEC22B SFTPC SLC30A8 SLC35A1 SMCO4 SMURF2 TMEM107 TMEM120B TMEM19 TMEM60 TRAF3IP3 UBIAD1 UPK1B VAMP5 YAP1 YIF1A ZFPL1	35 interacting genes: BSCL2 CD200R1 CD79A CLDN5 CPLX4 CREB3 CXCL9 FAM209A FNDC9 GJA8 GOLM1 GPR152 GPX8 HPN ICAM3 IFNGR2 KLRC1 LMNA LSMEM2 MUC1 NEDD4 PDZK1IP1 PQBP1 SEC22A SEC61G SIGLEC9 SMIM3 SYNE4 TMEM106C TMEM139 TMEM30B TMEM79 TMPRSS2 WWP1 WWP2
Entrez ID		135932	6440
HPRD ID		08298	01520
Ensembl ID		ENSG00000178826	ENSG00000168484
Uniprot IDs		Q8IV31	A0A0S2Z4Q0 E5RI64 P11686
PDB IDs			2YAD 8OVI 8OX2
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Golgi Membrane	Membrane Negative Regulation Of Potassium Ion Export Across Plasma Membrane
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