TMEM139 and ATP6V0C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM139	ATP6V0C
Description		transmembrane protein 139	ATPase H+ transporting V0 subunit c
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain Azurophil Granule Membrane Synapse Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding	Protein Binding Proton Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process		Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Proton Motive Force-driven ATP Synthesis Regulation Of Macroautophagy Positive Regulation Of Wnt Signaling Pathway Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs			Tiludronic acid
Diseases
GWAS
Interacting Genes		41 interacting genes: ABHD16A AGTRAP APOL2 ATP6V0C BCL2L2 CD151 CDS2 CLN6 CMTM5 CTSA CXCL16 CYB5B FAXDC2 KCNK1 MALL MARCHF5 MIP NAPB NEDD4 NINJ2 NKG7 NSG1 PLPP4 PMP22 SEC22B SFTPC SLC30A8 SLC35A1 SMCO4 SMURF2 TMEM107 TMEM120B TMEM19 TMEM60 TRAF3IP3 UBIAD1 UPK1B VAMP5 YAP1 YIF1A ZFPL1	54 interacting genes: AQP6 ARF6 ASGR2 CD53 CD69 CD79A CERS2 CLEC14A CLEC17A CLEC2D CLIC1 CPLX4 CREB3 DNAJC1 DRD2 EDA EDA2R ERBB2 ERGIC3 ERH EVI2A FAM210B FFAR2 GPR152 GPR25 GPR42 HSD17B13 HTR2C KLRC1 LMNA LRRC25 MARK3 MCEMP1 MDFI MSR1 NIPAL3 OPRM1 PDCD1LG2 PI16 PSMA3 RETREG3 SCN3B SLC35E3 SLC7A1 SMIM3 SPACA1 SSMEM1 STOM SUSD3 TMEM139 TMEM31 TMEM9 VSIR ZCCHC12
Entrez ID		135932	527
HPRD ID		08298	00162
Ensembl ID		ENSG00000178826	ENSG00000185883
Uniprot IDs		Q8IV31	P27449
PDB IDs			6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Golgi Membrane	Membrane Protein Binding Plasma Membrane Transmembrane Signaling Receptor Activity External Side Of Plasma Membrane Carbohydrate Binding G Protein-coupled Receptor Activity Fucose Binding Regulation Of Establishment Of Protein Localization Identical Protein Binding
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