TMEM139 and KCNK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM139	KCNK1
Description		transmembrane protein 139	potassium two pore domain channel subfamily K member 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Apical Plasma Membrane Dendrite Cytoplasmic Vesicle Brush Border Membrane Potassium Channel Complex Cell Projection Perikaryon Synapse Recycling Endosome Synaptic Membrane Inward Rectifier Potassium Channel Complex
	Molecular Function	Protein Binding	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Protein Heterodimerization Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process		Monoatomic Ion Transport Potassium Ion Transport Glutamate Secretion Monoatomic Ion Transmembrane Transport Response To Nicotine Sodium Ion Transmembrane Transport Regulation Of Resting Membrane Potential Regulation Of Postsynaptic Membrane Potential Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways			Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Phase 4 - resting membrane potential
Drugs			Ibutilide Quinidine Quinidine barbiturate
Diseases
GWAS			Cognitive function ( 28808816) Diabetic retinopathy ( 21441570) Periodontal microbiota ( 22699663) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		41 interacting genes: ABHD16A AGTRAP APOL2 ATP6V0C BCL2L2 CD151 CDS2 CLN6 CMTM5 CTSA CXCL16 CYB5B FAXDC2 KCNK1 MALL MARCHF5 MIP NAPB NEDD4 NINJ2 NKG7 NSG1 PLPP4 PMP22 SEC22B SFTPC SLC30A8 SLC35A1 SMCO4 SMURF2 TMEM107 TMEM120B TMEM19 TMEM60 TRAF3IP3 UBIAD1 UPK1B VAMP5 YAP1 YIF1A ZFPL1	13 interacting genes: AQP6 CDIPT CREB3 CREB3L1 ERGIC3 KRTAP10-3 LMNA SENP1 STOM TCIRG1 TMEM139 TMEM14B UBE2I
Entrez ID		135932	3775
HPRD ID		08298	03447
Ensembl ID		ENSG00000178826	ENSG00000135750
Uniprot IDs		Q8IV31	O00180
PDB IDs			3UKM
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Golgi Membrane	Nitrate Transmembrane Transporter Activity Negative Regulation Of Apoptotic Signaling Pathway Transcription Coregulator Binding Presynaptic Cytosol Postsynaptic Cytosol Protein Sumoylation SUMO Conjugating Enzyme Activity Dentin Mineralization Response To Silver Ion CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deacetylase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress PH-gated Chloride Channel Activity Nitrate Transmembrane Transport DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Memory T Cell Activation Alcohol Binding Endoplasmic Reticulum Unfolded Protein Response Retrograde Transporter Complex, Golgi To ER
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