HUS1B and RAD9A

Number of citations of the paper that reports this interaction (PMID 11944979)
7

Data Source:
HPRD (in vivo)

		HUS1B	RAD9A
Gene Name		HUS1 checkpoint homolog b (S. pombe)	RAD9 homolog A (S. pombe)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Checkpoint Clamp Complex	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex
	Molecular Function		Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding
	Biological Process	DNA Damage Checkpoint DNA Repair	DNA Replication Checkpoint DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Intra-S DNA Damage Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways			G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS		Aging ( 22773346)
Protein-Protein Interactions		4 interactors: HUS1 RAD1 RAD9A RAD9B	27 interactors: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CHEK2 CLSPN COPS5 DNAJC7 FEM1B HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 PCNA RAD17 RAD9B RPA1 RPA2 SF3B3 TOPBP1
Entrez ID		135458	5883
HPRD ID		13722	04788
Ensembl ID		ENSG00000188996	ENSG00000172613
Uniprot IDs		Q8NHY5	Q99638
PDB IDs			3A1J 3G65 3GGR
Enriched GO Terms of Interacting Partners?		DNA Damage Checkpoint Cell Cycle Checkpoint DNA Replication Cellular Response To Ionizing Radiation DNA Repair Cellular Response To Radiation Response To Ionizing Radiation Cellular Response To DNA Damage Stimulus Cell Cycle Process DNA Metabolic Process Cell Cycle DNA Catabolic Process, Exonucleolytic Cellular Response To Stress Response To Radiation Negative Regulation Of Cell Cycle DNA Catabolic Process Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Meiotic Recombination Checkpoint Response To Abiotic Stimulus Response To Stress Negative Regulation Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Cell Cycle Biosynthetic Process Intra-S DNA Damage Checkpoint DNA Replication Checkpoint Cellular Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Meiotic Nuclear Division Mitotic Cell Cycle Process Negative Regulation Of Meiotic Cell Cycle Mitotic Cell Cycle Cellular Response To Stimulus Substantia Nigra Development Regulation Of Meiosis Cellular Macromolecule Catabolic Process Negative Regulation Of DNA Replication Regulation Of Meiotic Cell Cycle Neural Nucleus Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination	Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress Mismatch Repair Cell Cycle Process DNA Metabolic Process Cell Cycle Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle DNA Recombination Response To Stress Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Metabolic Process Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Process Response To Ionizing Radiation Heterocycle Metabolic Process Double-strand Break Repair Cellular Nitrogen Compound Metabolic Process Meiotic Mismatch Repair Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of DNA Recombination Regulation Of DNA Recombination Cellular Response To Stimulus B Cell Activation Response To Radiation DNA Replication Positive Regulation Of Helicase Activity Meiotic Nuclear Division Somatic Recombination Of Immunoglobulin Gene Segments Apoptotic Process Somatic Diversification Of Immunoglobulins Programmed Cell Death Mitotic DNA Integrity Checkpoint Cell Death Meiotic Cell Cycle Death Meiosis I Response To Abiotic Stimulus B Cell Activation Involved In Immune Response Somatic Hypermutation Of Immunoglobulin Genes
Tagcloud ?			11q13 250k 4ebp1 8p12 affymetrix amplicon amplicons amplification arrays coamplification coamplifications coexpression cores eif4ebp1 enabled encompassing fgf19 fgf3 fgf4 fgfr1 gab2 gistic nspi oncogenes pak1 ppapdc1b rps6kb2 s6k2 synergy
Tagcloud (Difference) ?			11q13 250k 4ebp1 8p12 affymetrix amplicon amplicons amplification arrays coamplification coamplifications coexpression cores eif4ebp1 enabled encompassing fgf19 fgf3 fgf4 fgfr1 gab2 gistic nspi oncogenes pak1 ppapdc1b rps6kb2 s6k2 synergy
Tagcloud (Intersection) ?