HUS1B and RAD9A

Number of citations of the paper that reports this interaction (PubMedID 14611806)
0

Data Source:
HPRD (in vivo)

		HUS1B	RAD9A
Description		HUS1 checkpoint clamp component B	RAD9 checkpoint clamp component A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Checkpoint Clamp Complex Site Of Double-strand Break	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex
	Molecular Function		Nuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Nucleotide-excision Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Meiotic DNA Integrity Checkpoint Signaling	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways			Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Aging ( 22773346) Metabolite levels ( 23823483)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		4 interacting genes: HUS1 RAD1 RAD9A RAD9B	39 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CDK1 CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN
Entrez ID		135458	5883
HPRD ID		13722	04788
Ensembl ID		ENSG00000188996	ENSG00000172613
Uniprot IDs		Q8NHY5	Q99638
PDB IDs			3A1J 3G65 3GGR 6HM5 6J8Y 7Z6H 8GNN 8JZY 8WU8
Enriched GO Terms of Interacting Partners?		Checkpoint Clamp Complex Cellular Response To Ionizing Radiation DNA Damage Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling DNA Replication Checkpoint Signaling Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Cellular Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Response To Radiation Regulation Of Cell Cycle Phase Transition Double-stranded DNA 3'-5' DNA Exonuclease Activity DNA Repair Meiotic Cell Cycle Checkpoint Signaling DNA Metabolic Process Regulation Of Cell Cycle Process DNA Damage Response Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cellular Response To Stress Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Nucleic Acid Metabolic Process Meiotic DNA Integrity Checkpoint Signaling Nucleobase-containing Compound Metabolic Process Meiotic Recombination Checkpoint Signaling Response To Stress Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Replication Checkpoint Signaling Nucleoplasm 3'-5' Exonuclease Activity Signal Transduction Negative Regulation Of Meiotic Cell Cycle Macromolecule Metabolic Process Regulation Of Meiotic Nuclear Division Substantia Nigra Development Exonuclease Activity Mitotic G2/M Transition Checkpoint Nucleotide-excision Repair Regulation Of Meiotic Cell Cycle Damaged DNA Binding Neural Nucleus Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Reproductive Process	DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling DNA Recombination Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Mismatch Repair Response To Stress Regulation Of Cell Cycle Process Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Macromolecule Metabolic Process Nucleoplasm Intracellular Signal Transduction Response To Ionizing Radiation Response To Radiation Damaged DNA Binding Nucleus Regulation Of DNA Metabolic Process Protein Localization To Site Of Double-strand Break Recombinational Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Base-excision Repair Enzyme Binding Regulation Of Mitotic Cell Cycle DNA Replication Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Chromosome, Telomeric Region Somatic Cell DNA Recombination Mitotic DNA Replication Checkpoint Signaling Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Recombination Mismatched DNA Binding Regulation Of DNA Recombination Guanine/thymine Mispair Binding Mitotic G2/M Transition Checkpoint
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