HUS1B and RAD9B

Number of citations of the paper that reports this interaction (PubMedID 14611806)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HUS1B	RAD9B
Description		HUS1 checkpoint clamp component B	RAD9 checkpoint clamp component B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Checkpoint Clamp Complex Site Of Double-strand Break	Nucleus Nucleoplasm Checkpoint Clamp Complex
	Molecular Function		Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Nucleotide-excision Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Meiotic DNA Integrity Checkpoint Signaling	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation
Pathways			Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Aging ( 22773346) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: HUS1 RAD1 RAD9A RAD9B	5 interacting genes: HUS1 HUS1B RAD1 RAD17 RAD9A
Entrez ID		135458	144715
HPRD ID		13722	12221
Ensembl ID		ENSG00000188996	ENSG00000151164
Uniprot IDs		Q8NHY5	B4DX60 B4DYM6 J3KPN7 Q6WBX8
PDB IDs
Enriched GO Terms of Interacting Partners?		Checkpoint Clamp Complex Cellular Response To Ionizing Radiation DNA Damage Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling DNA Replication Checkpoint Signaling Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Cellular Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Response To Radiation Regulation Of Cell Cycle Phase Transition Double-stranded DNA 3'-5' DNA Exonuclease Activity DNA Repair Meiotic Cell Cycle Checkpoint Signaling DNA Metabolic Process Regulation Of Cell Cycle Process DNA Damage Response Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cellular Response To Stress Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Nucleic Acid Metabolic Process Meiotic DNA Integrity Checkpoint Signaling Nucleobase-containing Compound Metabolic Process Meiotic Recombination Checkpoint Signaling Response To Stress Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Replication Checkpoint Signaling Nucleoplasm 3'-5' Exonuclease Activity Signal Transduction Negative Regulation Of Meiotic Cell Cycle Macromolecule Metabolic Process Regulation Of Meiotic Nuclear Division Substantia Nigra Development Exonuclease Activity Mitotic G2/M Transition Checkpoint Nucleotide-excision Repair Regulation Of Meiotic Cell Cycle Damaged DNA Binding Neural Nucleus Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Reproductive Process	Checkpoint Clamp Complex DNA Replication Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling DNA Damage Checkpoint Signaling Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Phase Transition Meiotic Cell Cycle Checkpoint Signaling Negative Regulation Of Cell Cycle Process Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition DNA Repair Meiotic DNA Integrity Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle DNA Metabolic Process Regulation Of Cell Cycle Process DNA Damage Response Mitotic G2/M Transition Checkpoint Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Double-stranded DNA 3'-5' DNA Exonuclease Activity Site Of Double-strand Break Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Response To Ionizing Radiation Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Radiation Intracellular Signal Transduction Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleotide-excision Repair Response To Radiation Response To Stress Rad17 RFC-like Complex Telomere Maintenance Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Meiotic Recombination Checkpoint Signaling Signal Transduction Nucleolus Double-strand Break Repair Macromolecule Metabolic Process
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