HUS1B and RAD1

Number of citations of the paper that reports this interaction (PMID 11944979)
7

Data Source:
HPRD (in vivo, two hybrid)

		HUS1B	RAD1
Gene Name		HUS1 checkpoint homolog b (S. pombe)	RAD1 checkpoint DNA exonuclease
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Checkpoint Clamp Complex	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex Intracellular Membrane-bounded Organelle
	Molecular Function		Damaged DNA Binding Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity
	Biological Process	DNA Damage Checkpoint DNA Repair	DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Substantia Nigra Development Meiotic Recombination Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways			G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS		Aging ( 22773346)
Protein-Protein Interactions		4 interactors: HUS1 RAD1 RAD9A RAD9B	15 interactors: COPS5 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 PARK2 POLB RAD17 RAD9B RPA1 RPA2
Entrez ID		135458	5810
HPRD ID		13722	04400
Ensembl ID		ENSG00000188996	ENSG00000113456
Uniprot IDs		Q8NHY5	O60671
PDB IDs			3A1J 3G65 3GGR
Enriched GO Terms of Interacting Partners?		DNA Damage Checkpoint Cell Cycle Checkpoint DNA Replication Cellular Response To Ionizing Radiation DNA Repair Cellular Response To Radiation Response To Ionizing Radiation Cellular Response To DNA Damage Stimulus Cell Cycle Process DNA Metabolic Process Cell Cycle DNA Catabolic Process, Exonucleolytic Cellular Response To Stress Response To Radiation Negative Regulation Of Cell Cycle DNA Catabolic Process Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Meiotic Recombination Checkpoint Response To Abiotic Stimulus Response To Stress Negative Regulation Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Cell Cycle Biosynthetic Process Intra-S DNA Damage Checkpoint DNA Replication Checkpoint Cellular Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Meiotic Nuclear Division Mitotic Cell Cycle Process Negative Regulation Of Meiotic Cell Cycle Mitotic Cell Cycle Cellular Response To Stimulus Substantia Nigra Development Regulation Of Meiosis Cellular Macromolecule Catabolic Process Negative Regulation Of DNA Replication Regulation Of Meiotic Cell Cycle Neural Nucleus Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination	DNA Repair Cellular Response To Stress Cellular Response To DNA Damage Stimulus DNA Metabolic Process DNA Recombination Cell Cycle Process Mismatch Repair DNA Replication Meiotic Mismatch Repair DNA Damage Checkpoint Cell Cycle Response To Stress Negative Regulation Of DNA Metabolic Process Cell Cycle Checkpoint Positive Regulation Of Helicase Activity Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Base-excision Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of DNA Recombination Cellular Nitrogen Compound Metabolic Process Negative Regulation Of DNA Recombination Telomere Maintenance Via Semi-conservative Replication Nitrogen Compound Metabolic Process Nuclear DNA Replication Telomere Maintenance Via Recombination DNA-dependent DNA Replication Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Somatic Recombination Of Immunoglobulin Gene Segments Response To UV Somatic Diversification Of Immunoglobulins Maintenance Of DNA Repeat Elements Mitotic Cell Cycle Checkpoint Meiotic Nuclear Division Cellular Metabolic Process DNA Recombinase Assembly Cellular Response To Stimulus Mitotic Cell Cycle Immunoglobulin Production Meiotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Somatic Hypermutation Of Immunoglobulin Genes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Tagcloud ?			abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad9 repeats repressor rhino tethering topbp1 uv
Tagcloud (Difference) ?			abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad9 repeats repressor rhino tethering topbp1 uv
Tagcloud (Intersection) ?