COX5B and BHLHE40

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		COX5B	BHLHE40
Gene Name		cytochrome c oxidase subunit Vb	basic helix-loop-helix family, member e40
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Golgi Apparatus
	Molecular Function	Cytochrome-c Oxidase Activity Metal Ion Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Respiratory Gaseous Exchange Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Transmembrane Transport Hydrogen Ion Transmembrane Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Circadian Rhythm Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters	BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: AR BHLHE40 CCDC36 CDR2 KRT15 KRT31 LSM4 PNMA1 TFIP11 TRAF1 TRIM23	49 interactors: AAMP AANAT AES APH1A ARNTL BHLHE41 BRD7 BTRC CALML3 CCNK CDPF1 CHD3 COX5B DAB1 EHHADH ENO1 FBLN1 FBXW11 GMCL1P1 HDAC1 HIVEP1 KRTAP23-1 LARP4 MAGED1 MYOD1 NAA50 NOC4L NUMBL PDE6G PLEKHB2 PRKAA1 RBFOX1 RBM23 RBPMS RHOBTB3 RHOJ SETDB1 SIN3A SMYD1 SOX15 STAT3 STK19 TOB2 TOLLIP TTC23 TXNL4B VAC14 VIM ZHX1
Entrez ID		1329	8553
HPRD ID		00467	16050
Ensembl ID			ENSG00000134107
Uniprot IDs		P10606	O14503 Q6IB83
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Integrin Biosynthetic Process Spliceosomal Complex Disassembly Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Integrin Biosynthetic Process Regulation Of Integrin Biosynthetic Process	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Rhythmic Process RNA Metabolic Process Regulation Of Circadian Rhythm Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Gene Expression Circadian Rhythm Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Circadian Rhythm Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Histone Modification Chromatin Modification Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Process Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Skeletal Muscle Tissue Regeneration Positive Regulation Of Protein Metabolic Process Developmental Process Chromosome Organization Regulation Of Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription, DNA-templated Protein Acetylation Biosynthetic Process
Tagcloud ?		acidosis adaption adjunct analogous antitumoral carcinomas cd147 depend exists fulfillment glut1 glycolysis hnscc hpv immunological lactate lactic metabolite metabolize microenvironment oropharyngeal postulated returned situation sparse stronger transmembranous transportation warburg	ang angiogenic angiogenin cd31 colocalized fk fks glomeruli helix hypoxia lactate ldha microvascular mrnas mvd mvds nephrogenesis nks paired perinecrotic recapitulates reflected tubules univariable vegfa weaker wilms wts
Tagcloud (Difference) ?		acidosis adaption adjunct analogous antitumoral carcinomas cd147 depend exists fulfillment glut1 glycolysis hnscc hpv immunological lactic metabolite metabolize microenvironment oropharyngeal postulated returned situation sparse stronger transmembranous transportation warburg	ang angiogenic angiogenin cd31 colocalized fk fks glomeruli helix hypoxia ldha microvascular mrnas mvd mvds nephrogenesis nks paired perinecrotic recapitulates reflected tubules univariable vegfa weaker wilms wts
Tagcloud (Intersection) ?		lactate