BHLHE40 and PRR20A

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		BHLHE40	PRR20A
Name		basic helix-loop-helix family member e40	proline rich 20A
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Nuclear Body	None
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding	None
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis	None
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	None
GWAS		Cognitive function in longevity ( 33607172 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 31604244 ) Psoriasis vulgaris ( 26626624 ) Serum alkaline phosphatase levels ( 33547301 ) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355 )	Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862 ) Left ventricular end-diastolic volume (MTAG) ( 33495596 ) Left ventricular end-systolic volume (MTAG) ( 33495596 ) Left ventricular mass (MTAG) ( 33495596 ) Systolic blood pressure ( 30224653 ) Total cholesterol levels ( 33339817 )
Interacting Genes		91 interacting genes: AAMP AANAT APH1A ATXN1 BHLHE41 BMAL1 BRD7 BYSL CALML3 CCNK CDPF1 CHD3 COX5B CREM DAB1 DAZAP2 DVL3 EHHADH ENO1 FAM83A FBLN1 FXR1 GMCL2 GPSM1 HDAC1 HIVEP1 HNRNPLL KLHDC7B KRTAP1-3 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LARP4 LASP1 LMO3 MAGED1 MCRS1 MTCL2 MYOD1 NAA50 NEK6 NOC4L NUMBL PDE6G PFDN5 PHF1 PLEKHB2 POU6F2 PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E RAD54L2 RBFOX1 RBM11 RBM23 RBPMS RBPMS2 RHOBTB3 RHOJ ROR2 SETDB1 SIN3A SMAP2 SMARCB1 SMYD1 SOX15 STAT3 TCF3 TENT5A TENT5B TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I USP54 VAC14 VENTX VIM WHR1 WT1 ZFHX3 ZHX1	95 interacting genes: ABI2 ANKHD1 ARID5A ATXN1 BANP BEND2 BHLHE40 BICRAL C10orf55 C1orf94 C3orf36 CABP2 CCNK CDC37 CELF4 DAB1 DAZAP2 DMRT3 DVL3 EIF4ENIF1 ESRP1 FAM168A FAM222B FAM9A FOXH1 FOXP3 GATA2 GLIS2 GTF2A1 HIVEP1 HLX HYPK KRTAP19-1 KRTAP19-5 LASP1 MAGED1 MBNL3 NAA38 NCK2 NEDD9 NOTCH3 NTAQ1 OXER1 PATZ1 PHF1 PITX1 POGZ POU6F2 PRR20B PRR20C PRR20D PRR20E PRR34 PRR35 PTTG2 RBFOX1 RBM10 RBM23 RBM42 RBPMS RBPMS2 RHOXF2 RIPPLY1 RNF4 ROR2 SAMD11 SELENOV SH3RF1 SMAP1 SNRPB SNRPC SOX5 SP4 SRPK2 TBX3 TBX6 TCF7L2 TFG THAP1 TIAL1 TLX3 TOLLIP TPRX1 TRIM35 VAC14 VENTX VEZF1 VPS37C YPEL3 ZBTB32 ZC3H10 ZCCHC14 ZNF385C ZNF488 ZNF683
Entrez ID		8553	122183
HPRD ID		16050	13445
Ensembl ID		ENSG00000134107	ENSG00000204919
Uniprot IDs		O14503 Q6IB83	P86478 P86479 P86480 P86481 P86496
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Intermediate Filament Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Developmental Process Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Myoblast Differentiation Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Rhythmic Process Cytoplasmic Stress Granule Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process E-box Binding Transcription Corepressor Activity Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Circadian Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Circadian Rhythm Regulation Of Alternative MRNA Splicing, Via Spliceosome Chromatin Remodeling DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Myoblast Differentiation Regulation Of RNA Splicing Mitogen-activated Protein Kinase Kinase Kinase Binding	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Chromatin Protein Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Processing Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Negative Regulation Of Biosynthetic Process RNA Splicing Sequence-specific DNA Binding Cell Fate Commitment Nucleoplasm MRNA Binding Myoblast Fate Commitment Regulation Of Neuron Differentiation Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding