COX5B and LSM4

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		COX5B	LSM4
Description		cytochrome c oxidase subunit 5B	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytosol Membrane Protein-containing Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Ribonucleoprotein Complex
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Metal Ion Binding	RNA Binding Protein Binding U6 SnRNA Binding PH Domain Binding
	Biological Process	Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Respiratory Gaseous Exchange By Respiratory System Cellular Respiration Proton Transmembrane Transport	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process RNA Processing MRNA Processing RNA Splicing P-body Assembly
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs		Cholic Acid N-Formylmethionine
Diseases
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Chronotype ( 30696823) Estimated glomerular filtration rate ( 30604766) Gastroesophageal reflux disease ( 31527586) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 27863252 32888494) Reticulocyte count ( 32888494)
Interacting Genes		35 interacting genes: AR ARID5A BHLHE40 CDC42EP2 CDR2 CDR2L DOK3 FAM228A FLOT1 GOLGA2 IHO1 KRT15 KRT27 KRT31 KRT33B LSM4 MCCD1 MID2 NUDT5 OIP5 PLEKHF2 PNMA1 PRDM6 PRKAR1B PRR22 RBM48 SAXO4 SLAIN1 TASOR2 TEX12 TFIP11 TRAF1 TRIM23 TRIM27 VPS28	21 interacting genes: CALCOCO2 COX5B EXOSC8 GAS7 HOMEZ IKZF1 L3MBTL3 NMI PLEKHA5 PSTPIP1 RHOXF2 SLC22A2 SMIM14 SMN1 SMU1 SNRPE TOE1 TOP1 UBC XRN1 ZBTB10
Entrez ID		1329	25804
HPRD ID		00467	06284
Ensembl ID		ENSG00000135940	ENSG00000130520
Uniprot IDs		A0A384NL93 P10606	Q9Y4Z0 U3KQK1
PDB IDs		5Z62	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Supramolecular Fiber Organization Organelle Organization Intermediate Filament Cellular Response To Estrogen Stimulus Morphogenesis Of An Epithelium Cytoskeleton Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Cytoskeleton Organization Regulation Of Viral Transcription	Nucleoplasm SMN-Sm Protein Complex RRNA Catabolic Process Nuclear MRNA Surveillance Precatalytic Spliceosome SnRNA 3'-end Processing
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