BHLHE40 and NUMBL

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		BHLHE40	NUMBL
Name		basic helix-loop-helix family member e40	NUMB like endocytic adaptor protein
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Nuclear Body	Cytoplasm Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis	Nervous System Development Neuroblast Proliferation Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Forebrain Development Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis Regulation Of Postsynapse Assembly
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	None
GWAS		Cognitive function in longevity ( 33607172 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 31604244 ) Psoriasis vulgaris ( 26626624 ) Serum alkaline phosphatase levels ( 33547301 ) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355 )	Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941 ) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941 ) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941 ) Carotid intima media thickness (mean) ( 31801372 ) Kawasaki disease ( 22446962 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) tricyclic pyrone compound response (IC50) ( 33610756 )
Interacting Genes		91 interacting genes: AAMP AANAT APH1A ATXN1 BHLHE41 BMAL1 BRD7 BYSL CALML3 CCNK CDPF1 CHD3 COX5B CREM DAB1 DAZAP2 DVL3 EHHADH ENO1 FAM83A FBLN1 FXR1 GMCL2 GPSM1 HDAC1 HIVEP1 HNRNPLL KLHDC7B KRTAP1-3 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LARP4 LASP1 LMO3 MAGED1 MCRS1 MTCL2 MYOD1 NAA50 NEK6 NOC4L NUMBL PDE6G PFDN5 PHF1 PLEKHB2 POU6F2 PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E RAD54L2 RBFOX1 RBM11 RBM23 RBPMS RBPMS2 RHOBTB3 RHOJ ROR2 SETDB1 SIN3A SMAP2 SMARCB1 SMYD1 SOX15 STAT3 TCF3 TENT5A TENT5B TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I USP54 VAC14 VENTX VIM WHR1 WT1 ZFHX3 ZHX1	24 interacting genes: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 UBE3A YWHAG
Entrez ID		8553	9253
HPRD ID		16050	04931
Ensembl ID		ENSG00000134107	ENSG00000105245
Uniprot IDs		O14503 Q6IB83	A0A0C4DGH3 A8K033 B7Z5W0 Q9Y6R0
PDB IDs		Not available	3F0W
GO Terms Enriched among Interactors		Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Intermediate Filament Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Developmental Process Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Myoblast Differentiation Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Rhythmic Process Cytoplasmic Stress Granule Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process E-box Binding Transcription Corepressor Activity Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Circadian Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Circadian Rhythm Regulation Of Alternative MRNA Splicing, Via Spliceosome Chromatin Remodeling DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Myoblast Differentiation Regulation Of RNA Splicing Mitogen-activated Protein Kinase Kinase Kinase Binding	Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Interleukin-17-mediated Signaling Pathway Positive Regulation Of Signal Transduction Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Phosphate Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Amyloid Fibril Formation Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Protein Phosphorylation Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Phosphorylation Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Developmental Process Positive Regulation Of MAPK Cascade Regulation Of Cell Population Proliferation Protein Polyubiquitination Positive Regulation Of Metabolic Process Regulation Of Cell Communication Endosome Membrane Positive Regulation Of Apoptotic Signaling Pathway Macromolecule Catabolic Process Regulation Of Apoptotic Process Canonical NF-kappaB Signal Transduction Cytosol Tumor Necrosis Factor-mediated Signaling Pathway CD40 Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process CD40 Receptor Complex Regulation Of Primary Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Receptor Complex Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Signaling Adaptor Activity Positive Regulation Of Cell Population Proliferation