COX5B and CDC42EP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COX5B	CDC42EP2
Description		cytochrome c oxidase subunit 5B	CDC42 effector protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Endomembrane System Microtubule Cytoskeleton Membrane Phagocytic Vesicle
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Metal Ion Binding	Opioid Peptide Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Respiratory Gaseous Exchange By Respiratory System Cellular Respiration Proton Transmembrane Transport	Actin Filament Organization Rho Protein Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Type II Interferon
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly	MAPK6/MAPK4 signaling CDC42 GTPase cycle RHOQ GTPase cycle
Drugs		Cholic Acid N-Formylmethionine
Diseases
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Acne (severe) ( 24927181) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494)
Interacting Genes		35 interacting genes: AR ARID5A BHLHE40 CDC42EP2 CDR2 CDR2L DOK3 FAM228A FLOT1 GOLGA2 IHO1 KRT15 KRT27 KRT31 KRT33B LSM4 MCCD1 MID2 NUDT5 OIP5 PLEKHF2 PNMA1 PRDM6 PRKAR1B PRR22 RBM48 SAXO4 SLAIN1 TASOR2 TEX12 TFIP11 TRAF1 TRIM23 TRIM27 VPS28	11 interacting genes: ARHGAP26 CASS4 CDC42 COX5B NEDD9 NME7 PICK1 RHOQ SEPTIN6 SEPTIN7 SNCA
Entrez ID		1329	10435
HPRD ID		00467	09363
Ensembl ID		ENSG00000135940	ENSG00000149798
Uniprot IDs		A0A384NL93 P10606	O14613
PDB IDs		5Z62
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Supramolecular Fiber Organization Organelle Organization Intermediate Filament Cellular Response To Estrogen Stimulus Morphogenesis Of An Epithelium Cytoskeleton Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Cytoskeleton Organization Regulation Of Viral Transcription	Cytoskeleton Spindle Regulation Of Cytoskeleton Organization GBD Domain Binding Regulation Of Organelle Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Substrate Adhesion-dependent Cell Spreading Sperm Annulus Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Cellular Component Organization Septin Ring Septin Complex GTPase Activity Cell Division Site Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly GTP Binding Cell Projection Positive Regulation Of Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Phospholipid Binding Positive Regulation Of Cell-substrate Adhesion Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Synaptic Vesicle GTP Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Focal Adhesion Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Endocytosis Positive Regulation Of Filopodium Assembly Monoamine Transport Midbody Dendritic Spine Organization Supramolecular Fiber Organization Molecular Adaptor Activity Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Organization Organelle Organization Motile Cilium Protein Tyrosine Kinase Binding Regulation Of Cell-substrate Adhesion Cilium Neuron Projection Organization Cell Projection Organization Postsynapse Organization Regulation Of Cell Projection Assembly Regulation Of Filopodium Assembly Receptor Clustering Cleavage Furrow Actin Filament Organization
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