BHLHE40 and SOX15

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		BHLHE40	SOX15
Description		basic helix-loop-helix family member e40	SRY-box transcription factor 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Nuclear Body	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Male Gonad Development Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Cell Differentiation Neuron Differentiation Skeletal Muscle Tissue Regeneration Negative Regulation Of Striated Muscle Tissue Development Positive Regulation Of Transcription By RNA Polymerase II Myoblast Development Trophoblast Giant Cell Differentiation Positive Regulation Of G0 To G1 Transition Positive Regulation Of Myoblast Proliferation
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Drugs
Diseases
GWAS		Cognitive function in longevity ( 33607172) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Psoriasis vulgaris ( 26626624) Serum alkaline phosphatase levels ( 33547301) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Atrial fibrillation ( 30061737) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		91 interacting genes: AAMP AANAT APH1A ATXN1 BHLHE41 BMAL1 BRD7 BYSL CALML3 CCNK CDPF1 CHD3 COX5B CREM DAB1 DAZAP2 DVL3 EHHADH ENO1 FAM83A FBLN1 FXR1 GMCL2 GPSM1 HDAC1 HIVEP1 HNRNPLL KLHDC7B KRTAP1-3 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LARP4 LASP1 LMO3 MAGED1 MCRS1 MTCL2 MYOD1 NAA50 NEK6 NOC4L NUMBL PDE6G PFDN5 PHF1 PLEKHB2 POU6F2 PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E RAD54L2 RBFOX1 RBM11 RBM23 RBPMS RBPMS2 RHOBTB3 RHOJ ROR2 SETDB1 SIN3A SMAP2 SMARCB1 SMYD1 SOX15 STAT3 TCF3 TENT5A TENT5B TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I USP54 VAC14 VENTX VIM WHR1 WT1 ZFHX3 ZHX1	6 interacting genes: BHLHE40 CFTR HNF1B HSFY1 NFIC NFIX
Entrez ID		8553	6665
HPRD ID		16050	03191
Ensembl ID		ENSG00000134107	ENSG00000129194
Uniprot IDs		O14503 Q6IB83	O60248
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Intermediate Filament Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Developmental Process Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Myoblast Differentiation Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Rhythmic Process Cytoplasmic Stress Granule Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process E-box Binding Transcription Corepressor Activity Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Circadian Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Circadian Rhythm Regulation Of Alternative MRNA Splicing, Via Spliceosome Chromatin Remodeling DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Myoblast Differentiation Regulation Of RNA Splicing Mitogen-activated Protein Kinase Kinase Kinase Binding	DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Sequence-specific Double-stranded DNA Binding Odontogenesis Of Dentin-containing Tooth Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Odontogenesis Animal Organ Morphogenesis Positive Regulation Of Anion Channel Activity Negative Regulation Of RNA Metabolic Process Hepatoblast Differentiation Regulation Of Pronephros Size Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development DNA Replication Positive Regulation Of Enamel Mineralization Anterior/posterior Pattern Specification Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Nephric Duct Formation Transepithelial Water Transport Regulation Of RNA Metabolic Process Nephric Duct Development Mesonephric Duct Development Negative Regulation Of Somatic Stem Cell Population Maintenance MRF Binding Positive Regulation Of Tooth Mineralization Inner Cell Mass Cell Differentiation Regulation Of Kidney Size Endodermal Cell Fate Specification Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity
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