COX5B and NUDT5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COX5B	NUDT5
Description		cytochrome c oxidase subunit 5B	nudix hydrolase 5
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV	Nucleus Cytosol Extracellular Exosome
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Metal Ion Binding	Magnesium Ion Binding RNA Binding Protein Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity ADP-sugar Diphosphatase Activity SnoRNA Binding Identical Protein Binding Protein Homodimerization Activity 8-oxo-dGDP Phosphatase Activity Metal Ion Binding ADP-ribose Diphosphatase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity
	Biological Process	Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Respiratory Gaseous Exchange By Respiratory System Cellular Respiration Proton Transmembrane Transport	Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Nucleoside Phosphate Metabolic Process Nucleotide Metabolic Process Ribonucleoside Diphosphate Catabolic Process D-ribose Catabolic Process Ribose Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process ATP Generation From Poly-ADP-D-ribose
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly	Phosphate bond hydrolysis by NUDT proteins
Drugs		Cholic Acid N-Formylmethionine
Diseases
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		35 interacting genes: AR ARID5A BHLHE40 CDC42EP2 CDR2 CDR2L DOK3 FAM228A FLOT1 GOLGA2 IHO1 KRT15 KRT27 KRT31 KRT33B LSM4 MCCD1 MID2 NUDT5 OIP5 PLEKHF2 PNMA1 PRDM6 PRKAR1B PRR22 RBM48 SAXO4 SLAIN1 TASOR2 TEX12 TFIP11 TRAF1 TRIM23 TRIM27 VPS28	5 interacting genes: COX5B GORASP2 MAPK6 MCM3AP NUDT3
Entrez ID		1329	11164
HPRD ID		00467	14851
Ensembl ID		ENSG00000135940	ENSG00000165609
Uniprot IDs		A0A384NL93 P10606	Q9UKK9
PDB IDs		5Z62	2DSB 2DSC 2DSD 3AC9 3ACA 3BM4 3L85 5NQR 5NWH 5QJ4 5QJ5 5QJ6 5QJ7 5QJ8 5QJ9 5QJA 5QJB 5QJC 5QJD 5QJE 5QJF 5QJG 5QJH 5QJI 5QJJ 5QJK 5QJL 5QJM 5QJN 5QJO 5QJP 5QJQ 5QJR 5QJS 5QJT 5QJU 5QJV 5QJW 5QJX 5QJY 5QJZ 5QK0 5QK1 5QK2 5QK3 5QK4 5QK5 5QK6 5QK7 5QK8 5QK9 5QKA 5QKB 5QTL 5QTM 5QTN 5QTO 5QTP 5QTQ 5QTR 5QTS 6GRU 8PTT 8RDZ 8RIY
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Supramolecular Fiber Organization Organelle Organization Intermediate Filament Cellular Response To Estrogen Stimulus Morphogenesis Of An Epithelium Cytoskeleton Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Cytoskeleton Organization Regulation Of Viral Transcription	Regulation Of Cellular Response To X-ray Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Type IV Hypersensitivity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Pro-T Cell Differentiation Parathyroid Hormone Secretion Septin Cytoskeleton 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Nephric Duct Formation Regulation Of Thyroid Hormone Generation Positive Regulation Of Ureteric Bud Formation Ureter Maturation Positive Regulation Of Thyroid Hormone Generation Mast Cell Differentiation Bis(5'-adenosyl)-pentaphosphatase Activity Diadenosine Polyphosphate Catabolic Process Ureteric Bud Formation Interleukin-2 Receptor Binding Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Cell Proliferation Involved In Kidney Development Immune System Development Transcription Export Complex 2 Parathyroid Gland Development Mesonephric Tubule Formation Ureter Morphogenesis Otic Vesicle Development Nephric Duct Morphogenesis Norepinephrine Biosynthetic Process Histone H3 Acetyltransferase Activity T-helper 2 Cell Differentiation Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Epithelial Tube Formation Cellular Response To Interferon-alpha 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Cytochrome-c Oxidase Activity Positive Regulation Of Transcription Regulatory Region DNA Binding
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