BHLHE40 and SMARCB1

Number of citations: 45 (PubMedID 27229929)
Data Source: BioGRID (two hybrid)

		BHLHE40	SMARCB1
Name		basic helix-loop-helix family member e40	SWI/SNF related BAF chromatin remodeling complex subunit B1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Nuclear Body	Nuclear Chromosome Kinetochore Chromatin Fibrillar Center XY Body Nucleus Nucleoplasm Nucleolus Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex Germ Cell Nucleus NpBAF Complex NBAF Complex BBAF Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding P53 Binding DNA Binding Transcription Coactivator Activity Protein Binding Tat Protein Binding Nucleosomal DNA Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis	RNA Polymerase I Preinitiation Complex Assembly Blastocyst Development Blastocyst Hatching Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Negative Regulation Of Cell Population Proliferation DNA Integration Regulation Of Mitotic Metaphase/anaphase Transition Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Host-mediated Activation Of Viral Transcription Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of G0 To G1 Transition Hepatocyte Differentiation Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
GWAS		Cognitive function in longevity ( 33607172 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 31604244 ) Psoriasis vulgaris ( 26626624 ) Serum alkaline phosphatase levels ( 33547301 ) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355 )	Dilated cardiomyopathy ( 33677556 ) Dilated cardiomyopathy (MTAG) ( 33495596 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Fractional shortening ( 29403010 ) Hypertrophic cardiomyopathy ( 33495596 ) Hypertrophic cardiomyopathy (MTAG) ( 33495596 ) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392 ) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG disialylation phenotypes (multivariate analysis) ( 28878392 ) IgG fucosylation phenotypes (multivariate analysis) ( 28878392 ) IgG galactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG glycosylation ( 23382691 ) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391 ) IgG sialylation phenotypes (multivariate analysis) ( 28878392 ) Left ventricle wall thickness ( 33495596 ) Left ventricular end-systolic volume ( 33495596 ) Left ventricular global circumferential strain ( 33495596 ) Left ventricular global radial strain ( 33495596 ) Left ventricular mass to end-diastolic volume ratio ( 33495596 ) N-glycan levels ( 31163085 )
Interacting Genes		91 interacting genes: AAMP AANAT APH1A ATXN1 BHLHE41 BMAL1 BRD7 BYSL CALML3 CCNK CDPF1 CHD3 COX5B CREM DAB1 DAZAP2 DVL3 EHHADH ENO1 FAM83A FBLN1 FXR1 GMCL2 GPSM1 HDAC1 HIVEP1 HNRNPLL KLHDC7B KRTAP1-3 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LARP4 LASP1 LMO3 MAGED1 MCRS1 MTCL2 MYOD1 NAA50 NEK6 NOC4L NUMBL PDE6G PFDN5 PHF1 PLEKHB2 POU6F2 PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E RAD54L2 RBFOX1 RBM11 RBM23 RBPMS RBPMS2 RHOBTB3 RHOJ ROR2 SETDB1 SIN3A SMAP2 SMARCB1 SMYD1 SOX15 STAT3 TCF3 TENT5A TENT5B TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I USP54 VAC14 VENTX VIM WHR1 WT1 ZFHX3 ZHX1	111 interacting genes: ABI2 AKT1 APP ARL11 ATP5F1A BCL2L11 BHLHE40 BLZF1 CALR CAMK2D CCDC120 CCDC33 CD69 CDC23 CDX2 CEBPB CHFR CXCL11 CYB5D2 DNAJA3 DPH6 EZH2 FAM90A1 FAM9B FUS GADD45G GATA1 GFAP GOLGA2 HGS HNRNPM HOMEZ HOOK2 HSF2BP HSFY1 IHO1 IKZF3 IL16 KCTD9 KLC3 KLF1 KMT2B KMT2C KPNA6 KRT15 KRT19 KRT6A KRT6B KRT6C LDOC1 LENG8 LNX2 LY96 LZTS2 MAP1LC3B MAP3K20 MAPK8IP2 MBIP MCPH1 MECP2 MESD MIF4GD MRPL53 MXI1 MYC NCK2 NONO NR0B2 NR3C1 OSGIN1 OTX2 PDPK1 PICK1 PPP1CC PPP1R15A PRKAB2 PSMB1 RAN RB1 RELB RINT1 RPN1 RPS6KA5 RUSC1 RXRA SAXO1 SIN3B SMARCA4 SRC TACC2 TAF1D TASOR2 TEKT5 TFIP11 TLE5 TNFAIP1 TNRC6A TP53 TRIM14 TRIM27 TRIM35 TSC22D4 UBQLN4 UBR5 VIM XPO1 YEATS4 ZC3H11A ZDHHC17 ZNF398 ZNF688
Entrez ID		8553	6598
HPRD ID		16050	03364
Ensembl ID		ENSG00000134107	ENSG00000099956
Uniprot IDs		O14503 Q6IB83	G5E975 Q12824 Q9H836
PDB IDs		Not available	5AJ1 5GJK 5L7A 5L7B 6AX5 6KAG 6KZ7 6LTH 6LTJ 6LZP 6UCH 7VDV 7Y8R
GO Terms Enriched among Interactors		Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Intermediate Filament Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Developmental Process Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Myoblast Differentiation Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Rhythmic Process Cytoplasmic Stress Granule Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process E-box Binding Transcription Corepressor Activity Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Circadian Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Circadian Rhythm Regulation Of Alternative MRNA Splicing, Via Spliceosome Chromatin Remodeling DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Myoblast Differentiation Regulation Of RNA Splicing Mitogen-activated Protein Kinase Kinase Kinase Binding	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleus Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Protein Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleoplasm Organelle Organization Protein-containing Complex Positive Regulation Of Macromolecule Biosynthetic Process Cytoskeleton Organization Intermediate Filament Organization Positive Regulation Of Macromolecule Metabolic Process Supramolecular Fiber Organization Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Regulation Of Metabolic Process Intermediate Filament Cytoskeleton Organization Protein Domain Specific Binding Intermediate Filament-based Process Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Lymphocyte Apoptotic Process Structural Constituent Of Cytoskeleton Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Regulation Of Glial Cell Proliferation Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cytosol Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Cellular Developmental Process Positive Regulation Of RNA Metabolic Process Signal Complex Assembly