UBE2M and DCUN1D1

Number of citations of the paper that reports this interaction (PubMedID 35544948)
0

Data Source:
BioGRID (pull down)

		UBE2M	DCUN1D1
Description		ubiquitin conjugating enzyme E2 M	defective in cullin neddylation 1 domain containing 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Presynapse Postsynapse Glutamatergic Synapse	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Protein Modification By Small Protein Conjugation Protein Modification Process Post-translational Protein Modification Protein Neddylation Regulation Of Postsynapse Assembly	Regulation Of Protein Ubiquitination Protein Neddylation Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation
Pathways		TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Fasting insulin ( 34074324) Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)
Interacting Genes		34 interacting genes: APP CAND1 CBL CFL1 CPNE1 CPNE2 CPNE4 CUL1 CUL2 CUL4A CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 NFKBIA PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3	32 interacting genes: ABRAXAS2 ARIH1 ARIH2 ARRDC3 AURKB CALM1 CDIP1 CUL5 DAZAP2 DVL2 FAM168A GMPPA LAPTM5 LZTS2 MAP3K1 NEDD4 PLEKHB2 RHOA RNF11 SMAD2 SUSD6 TLE5 TMEM239 TP53BP2 TRIM39 TRIM54 TRIM8 UBC UBE2D3 UBE2F UBE2M VPS37B
Entrez ID		9040	54165
HPRD ID		04414	12067
Ensembl ID		ENSG00000130725	ENSG00000043093
Uniprot IDs		A0A024R4T4 P61081	B4DM76 C9JVE2 Q96GG9
PDB IDs		1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O	3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W 6XOL 6XOM 6XON 6XOO 6XOP 6XOQ 7KWA 8OR2 8OR3
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Protein Modification Process Protein Ubiquitination Cullin Family Protein Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Protein Metabolic Process Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Protein Polyubiquitination Regulation Of Protein Neddylation Ubiquitin Ligase Complex Scaffold Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleus Cytosol Cytoplasm Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Catabolic Process Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity Regulation Of Mitophagy Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Of Mitochondrion NEDD8 Transferase Activity Positive Regulation Of Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Proteasomal Protein Catabolic Process	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process NEDD8 Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Midbody NEDD8 Transferase Activity Ubiquitin Ligase Complex Cleavage Furrow Formation Mitotic Spindle Assembly Macromolecule Catabolic Process Protein Targeting To Vacuole Innate Immune Response Negative Regulation Of Signal Transduction Protein Polyubiquitination Transferase Activity Establishment Of Protein Localization To Vacuole Proteolysis Spindle Midzone Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Mitotic Cytokinesis Cytosol Intrinsic Apoptotic Signaling Pathway Vesicle Protein K63-linked Ubiquitination Cul5-RING Ubiquitin Ligase Complex Endosome Defense Response To Symbiont Negative Regulation Of CGAS/STING Signaling Pathway Defense Response To Other Organism Protein Binding Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Cytokinesis Ubiquitin-like Protein Transferase Activity Spindle Assembly Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Protein Localization To Vacuole Protein Neddylation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?