UBE2M and DCUN1D4

Number of citations: 60 (PubMedID 28581483)
Data Source: BioGRID (pull down)

		UBE2M	DCUN1D4
Name		ubiquitin conjugating enzyme E2 M	defective in cullin neddylation 1 domain containing 4
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Presynapse Postsynapse Glutamatergic Synapse	Ubiquitin Ligase Complex Nucleus
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Protein Modification By Small Protein Conjugation Protein Modification Process Post-translational Protein Modification Protein Neddylation Regulation Of Postsynapse Assembly	Protein Neddylation Positive Regulation Of Protein Neddylation
Pathways		TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation
GWAS		Mean corpuscular hemoglobin ( 32888494 )	Estimated glomerular filtration rate ( 31152163 ) Familial squamous cell lung carcinoma ( 29924316 ) Height ( 28552196 )
Novel Interactors		None recorded	1 novel interactors: CEP135
Interacting Genes		34 interacting genes: APP CAND1 CBL CFL1 CPNE1 CPNE2 CPNE4 CUL1 CUL2 CUL4A CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 NFKBIA PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3	7 interacting genes: CAND1 CUL2 CUL3 CUL4A CUL4B UBE2M VAV2
Entrez ID		9040	23142
HPRD ID		04414	13791
Ensembl ID		ENSG00000130725	ENSG00000109184
Uniprot IDs		A0A024R4T4 P61081	B4DH26 Q92564
PDB IDs		1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O	5V89
GO Terms Enriched among Interactors		Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Protein Modification Process Protein Ubiquitination Cullin Family Protein Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Protein Metabolic Process Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Protein Polyubiquitination Regulation Of Protein Neddylation Ubiquitin Ligase Complex Scaffold Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleus Cytosol Cytoplasm Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Catabolic Process Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity Regulation Of Mitophagy Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Of Mitochondrion NEDD8 Transferase Activity Positive Regulation Of Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Proteasomal Protein Catabolic Process	Cullin-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Cell Cycle Phase Transition Protein Ubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Mitotic Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Protein Modification Process Cul4A-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Proteasomal Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Cul4-RING E3 Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Type I Interferon-mediated Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Interferon-mediated Signaling Pathway Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Macromolecule Catabolic Process Regulation Of Cell Cycle Phase Transition Trophectodermal Cellular Morphogenesis Liver Morphogenesis NEDD8 Conjugating Enzyme Activity SCF Complex Assembly Cellular Response To Light Stimulus Regulation Of Mitotic Cell Cycle Proteolysis Ribosome Biogenesis Regulation Protein Catabolic Process At Postsynapse Cytosol POZ Domain Binding Response To UV Regulation Of G1/S Transition Of Mitotic Cell Cycle