UBE2M and DCUN1D3

Number of citations of the paper that reports this interaction (PMID 19617556)
19

Data Source:
BioGRID (pull down, pull down)

		UBE2M	DCUN1D3
Gene Name		ubiquitin-conjugating enzyme E2M	DCN1, defective in cullin neddylation 1, domain containing 3
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ribosomal S6-glutamic Acid Ligase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Molecular_function
	Biological Process	Cellular Protein Modification Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Ubiquitination Positive Regulation Of Neuron Apoptotic Process Protein Neddylation	Response To UV-C Response To Gamma Radiation Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL3 CUL7 DCUN1D3 DCUN1D4 MARCH7 MDM2 NAE1 NEDD4 NEDD8 PARK2 PINK1 RBX1 RNF111 RNF7 TP53 UBA3 UBC	4 interactors: CUL4A CUL4B CUL5 UBE2M
Entrez ID		9040	123879
HPRD ID		04414	14660
Ensembl ID		ENSG00000130725
Uniprot IDs		P61081	Q8IWE4
PDB IDs		1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO	4GBA
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Neddylation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Protein Monoubiquitination Proteolysis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hypoxia Regulation Of Mitochondrion Degradation Cellular Response To Decreased Oxygen Levels Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cellular Response To Oxygen Levels Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Catabolic Process Notch Signaling Pathway Regulation Of Cell Cycle Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Catabolic Process Viral Process Protein Polyubiquitination Negative Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Apoptotic Process Cellular Response To Toxic Substance Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process Signaling Mitotic Cell Cycle Process Response To Oxidative Stress	Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Nucleotide-excision Repair Cellular Macromolecule Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle Arrest Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cellular Protein Modification Process Intrinsic Apoptotic Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Proteolysis UV-damage Excision Repair Cellular Protein Metabolic Process Negative Regulation Of Granulocyte Differentiation Apoptotic Signaling Pathway Protein Neddylation Catabolic Process Regulation Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Histone H2A Monoubiquitination Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Histone H2A Ubiquitination Protein Metabolic Process Viral Process Histone Monoubiquitination DNA Repair Negative Regulation Of Cell Proliferation Mitotic Cell Cycle Process Mitotic Cell Cycle Histone Ubiquitination Cellular Response To Stimulus
Tagcloud ?		acts affects balance brca1 breaks choice controller controlling ctip cytotoxic deneddylation great homologous indeed neddylation nhej recombination repair repaired resection respond rnf111 ssdna strand subpathways tight toward uncover way
Tagcloud (Difference) ?		acts affects balance brca1 breaks choice controller controlling ctip cytotoxic deneddylation great homologous indeed neddylation nhej recombination repair repaired resection respond rnf111 ssdna strand subpathways tight toward uncover way
Tagcloud (Intersection) ?