UBE2M

Description		ubiquitin conjugating enzyme E2 M
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity
	Biological Process	Protein Modification By Small Protein Conjugation Protein Modification Process Post-translational Protein Modification Protein Neddylation Regulation Of Postsynapse Assembly
Pathways		TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		34 interacting genes: APP CAND1 CBL CFL1 CPNE1 CPNE2 CPNE4 CUL1 CUL2 CUL4A CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 NFKBIA PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3
Entrez ID		9040
HPRD ID		04414
Ensembl ID		ENSG00000130725
Uniprot IDs		A0A024R4T4 P61081
PDB IDs		1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Protein Modification Process Protein Ubiquitination Cullin Family Protein Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Protein Metabolic Process Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Protein Polyubiquitination Regulation Of Protein Neddylation Ubiquitin Ligase Complex Scaffold Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleus Cytosol Cytoplasm Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Catabolic Process Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity Regulation Of Mitophagy Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Of Mitochondrion NEDD8 Transferase Activity Positive Regulation Of Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Proteasomal Protein Catabolic Process
Tagcloud ?