UBE2M and CAND1

Number of citations of the paper that reports this interaction (PubMedID 29499133)
55

Data Source:
BioGRID (pull down)

		UBE2M	CAND1
Description		ubiquitin conjugating enzyme E2 M	cullin associated and neddylation dissociated 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Presynapse Postsynapse Glutamatergic Synapse	Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cullin-RING Ubiquitin Ligase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity	Protein Binding TBP-class Protein Binding
	Biological Process	Protein Modification By Small Protein Conjugation Protein Modification Process Post-translational Protein Modification Protein Neddylation Regulation Of Postsynapse Assembly	SCF Complex Assembly Protein Ubiquitination Cell Differentiation Negative Regulation Of Catalytic Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Pathways		TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neutrophil degranulation Neddylation Iron uptake and transport
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Expressive vocabulary in infants ( 25226531) HDL cholesterol levels ( 32203549) Hippocampal atrophy ( 19668339) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549)
Interacting Genes		34 interacting genes: APP CAND1 CBL CFL1 CPNE1 CPNE2 CPNE4 CUL1 CUL2 CUL4A CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 NFKBIA PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3	20 interacting genes: CA9 CEBPA CNOT3 CUL1 CUL2 CUL3 CUL4A CUL4B DCUN1D2 DCUN1D4 DCUN1D5 DUX4 FILNC1 HSPA13 MTNR1A RBX1 RNF10 SKP1 SRPK2 UBE2M
Entrez ID		9040	55832
HPRD ID		04414	06983
Ensembl ID		ENSG00000130725	ENSG00000111530
Uniprot IDs		A0A024R4T4 P61081	Q86VP6
PDB IDs		1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O	1U6G 4A0C 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8CDJ 8CDK 8H3Q 8OR0 8OR2 8OR3 8OR4
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Protein Modification Process Protein Ubiquitination Cullin Family Protein Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Protein Metabolic Process Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Protein Polyubiquitination Regulation Of Protein Neddylation Ubiquitin Ligase Complex Scaffold Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleus Cytosol Cytoplasm Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Catabolic Process Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity Regulation Of Mitophagy Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Of Mitochondrion NEDD8 Transferase Activity Positive Regulation Of Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Proteasomal Protein Catabolic Process	Cullin-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Cullin Family Protein Binding G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Protein Modification Process Protein Monoubiquitination Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Cul4A-RING E3 Ubiquitin Ligase Complex Proteolysis Involved In Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Regulation Of Protein Neddylation Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Protein Metabolic Process Cul4-RING E3 Ubiquitin Ligase Complex Nucleus Macromolecule Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Binding Cul7-RING Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Base-excision Repair, AP Site Formation Via Deaminated Base Removal NEDD8 Transferase Activity Protein Polyubiquitination Regulation Of Cell Cycle Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Epithelial Cell Apoptotic Process Type I Interferon-mediated Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle
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