COL4A4 and SAA1

Number of citations of the paper that reports this interaction (PMID 8995276)
1

Data Source:
HPRD (in vitro)

		COL4A4	SAA1
Gene Name		collagen, type IV, alpha 4	serum amyloid A1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basal Lamina Endoplasmic Reticulum Lumen	Extracellular Region High-density Lipoprotein Particle Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Extracellular Matrix Structural Constituent	G-protein Coupled Receptor Binding Heparin Binding
	Biological Process	Axon Guidance Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Glomerular Basement Membrane Development	Receptor-mediated Endocytosis Acute-phase Response Positive Regulation Of Cytosolic Calcium Ion Concentration Platelet Activation Neutrophil Chemotaxis Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Interleukin-1 Secretion Negative Regulation Of Inflammatory Response
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Toll Like Receptor 7/8 (TLR7/8) Cascade Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade Formyl peptide receptors bind formyl peptides and many other ligands DEx/H-box helicases activate type I IFN and inflammatory cytokines production Amyloids Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Peptide ligand-binding receptors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane G alpha (i) signalling events Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA GPCR ligand binding MyD88-independent cascade G alpha (q) signalling events Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways GPCR downstream signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRAF6 mediated NF-kB activation Scavenging by Class B Receptors TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)	Amyloid A Levels ( 21124955)
Protein-Protein Interactions		12 interactors: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 TGFBI	8 interactors: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 LAMA1 VIMP VKORC1
Entrez ID		1286	6288
HPRD ID		00360	00097
Ensembl ID		ENSG00000081052	ENSG00000173432
Uniprot IDs		P53420	P0DJI8
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Response To Wounding Wound Healing Endodermal Cell Differentiation Acute-phase Response Leukocyte Migration Regulation Of Cell Adhesion Peptide Cross-linking Endoderm Formation Seminal Vesicle Epithelium Development Dendrite Regeneration Anatomical Structure Morphogenesis Cell Migration Acute Inflammatory Response Cell Motility Endoderm Development Negative Regulation Of Transport Tissue Development Negative Regulation Of Ion Transport Mating Plug Formation Blood Coagulation Hemostasis Response To External Stimulus Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein System Development Formation Of Primary Germ Layer Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Receptor Binding Calcium-independent Cell-matrix Adhesion Cell Adhesion Positive Regulation Of Keratinocyte Migration Negative Regulation Of Plasminogen Activation Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Body Fluid Levels Locomotion Immune System Process Chemotaxis Regulation Of Growth Reproductive Process Nervous System Development Multicellular Organismal Development Response To Stress Gastrulation Platelet Activation Cell Activation Negative Regulation Of Platelet Aggregation Tyrosine Phosphorylation Of STAT Protein	Collagen Catabolic Process Chemotaxis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Response To External Stimulus Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Neuron Projection Morphogenesis Retinal Blood Vessel Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Retina Vasculature Morphogenesis In Camera-type Eye Cell Morphogenesis Glomerular Basement Membrane Development Neuron Differentiation Cell Projection Organization Retina Vasculature Development In Camera-type Eye Generation Of Neurons Neurogenesis Catabolic Process Cell Development Renal System Development Glomerulus Development Response To Stimulus Urogenital System Development Blood Vessel Morphogenesis Negative Regulation Of Angiogenesis Regulation Of Nitric Oxide Metabolic Process Nervous System Development Anatomical Structure Morphogenesis Blood Vessel Development Vasculature Development System Development Endothelial Cell Apoptotic Process Nephron Development Multicellular Organismal Development Organ Development Negative Regulation Of Macrophage Apoptotic Process Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process
Tagcloud ?		alport basement clarification classic diagnostics families focal fsgs gbm glomerulosclerosis hematuria hereditary heterozygous histologic illustrates inconsistent inherited interpretation nephritis nephropathy nephrotic pathognomonic predominant proteinuria segmental segregated thin variants	10scn 1rn alleles amyloidosis c57bl chemotaxis del deposit differently efficacious encoded equally familiar fever formyl fpr2 isoforms mediterranean mobilization modulating predominant preference robust saa2 selectivity tlr2 tlr4lps toll
Tagcloud (Difference) ?		alport basement clarification classic diagnostics families focal fsgs gbm glomerulosclerosis hematuria hereditary heterozygous histologic illustrates inconsistent inherited interpretation nephritis nephropathy nephrotic pathognomonic proteinuria segmental segregated thin variants	10scn 1rn alleles amyloidosis c57bl chemotaxis del deposit differently efficacious encoded equally familiar fever formyl fpr2 isoforms mediterranean mobilization modulating preference robust saa2 selectivity tlr2 tlr4lps toll
Tagcloud (Intersection) ?		predominant