COL4A4 and FBLN2

Number of citations of the paper that reports this interaction (PMID 7500359)
18

Data Source:
HPRD (in vivo)

		COL4A4	FBLN2
Gene Name		collagen, type IV, alpha 4	fibulin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basal Lamina Endoplasmic Reticulum Lumen	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix Vesicle Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent	Extracellular Matrix Structural Constituent Calcium Ion Binding Extracellular Matrix Binding
	Biological Process	Axon Guidance Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Glomerular Basement Membrane Development	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)	Bipolar disorder (mood-incongruent) ( 23092984)
Protein-Protein Interactions		12 interactors: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 TGFBI	22 interactors: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ELN FBN1 FN1 HSPG2 ITGB3 LAMA1 LAMA5 LAMC2 NID1 PRELP VCAN ZNF408
Entrez ID		1286	2199
HPRD ID		00360	00630
Ensembl ID		ENSG00000081052	ENSG00000163520
Uniprot IDs		P53420	F5H1F3 P98095 Q86V58 Q9Y3V7
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Response To Wounding Wound Healing Endodermal Cell Differentiation Acute-phase Response Leukocyte Migration Regulation Of Cell Adhesion Peptide Cross-linking Endoderm Formation Seminal Vesicle Epithelium Development Dendrite Regeneration Anatomical Structure Morphogenesis Cell Migration Acute Inflammatory Response Cell Motility Endoderm Development Negative Regulation Of Transport Tissue Development Negative Regulation Of Ion Transport Mating Plug Formation Blood Coagulation Hemostasis Response To External Stimulus Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein System Development Formation Of Primary Germ Layer Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Receptor Binding Calcium-independent Cell-matrix Adhesion Cell Adhesion Positive Regulation Of Keratinocyte Migration Negative Regulation Of Plasminogen Activation Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Body Fluid Levels Locomotion Immune System Process Chemotaxis Regulation Of Growth Reproductive Process Nervous System Development Multicellular Organismal Development Response To Stress Gastrulation Platelet Activation Cell Activation Negative Regulation Of Platelet Aggregation Tyrosine Phosphorylation Of STAT Protein	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Anatomical Structure Development System Development Developmental Process Multicellular Organismal Development Cell Adhesion Cell Morphogenesis Involved In Differentiation Glycosaminoglycan Catabolic Process Cardiovascular System Development Blood Vessel Morphogenesis Locomotion Catabolic Process Blood Vessel Development Cell Morphogenesis Nervous System Development Angiogenesis Vasculature Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Glycosaminoglycan Biosynthetic Process Axon Guidance Tissue Development Cell-substrate Junction Assembly Cell Development Organ Development Axonogenesis Glomerular Basement Membrane Development Renal System Development Cell Projection Morphogenesis Glycosaminoglycan Metabolic Process Axon Development Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Urogenital System Development Pathogenesis Neuron Projection Morphogenesis Cell Differentiation Proteoglycan Metabolic Process Cell Projection Organization Neuron Projection Development Retinal Blood Vessel Morphogenesis Kidney Development Neurogenesis
Tagcloud ?		alport basement clarification classic diagnostics families focal fsgs gbm glomerulosclerosis hematuria hereditary heterozygous histologic illustrates inconsistent inherited interpretation nephritis nephropathy nephrotic pathognomonic predominant proteinuria segmental segregated thin variants	3p 3p24 anonymous arrayed candidate chromosomal closely colocation d3s1585 excluded fibulin generated intragenic linkage locus lod map marfan marker markers matrix mfs2 p25 placed point polymorphic polymorphisms scores sequencing
Tagcloud (Difference) ?		alport basement clarification classic diagnostics families focal fsgs gbm glomerulosclerosis hematuria hereditary heterozygous histologic illustrates inconsistent inherited interpretation nephritis nephropathy nephrotic pathognomonic predominant proteinuria segmental segregated thin variants	3p 3p24 anonymous arrayed candidate chromosomal closely colocation d3s1585 excluded fibulin generated intragenic linkage locus lod map marfan marker markers matrix mfs2 p25 placed point polymorphic polymorphisms scores sequencing
Tagcloud (Intersection) ?