COL4A4

Description		collagen type IV alpha 4 chain
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Molecular Adaptor Activity
	Biological Process	Glomerular Basement Membrane Development
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs		TRC093
Diseases		Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Birth weight ( 31043758) Body mass index ( 25673413 28270201) Coronary artery disease ( 29212778) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Macular thickness ( 30535121) Systolic blood pressure ( 30578418) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189)
Interacting Genes		13 interacting genes: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 MTDH OSM SAA1 SERPINE2 TGFBI
Entrez ID		1286
HPRD ID		00360
Ensembl ID		ENSG00000081052
Uniprot IDs		P53420
PDB IDs		5NB1 6WKU
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Glycosaminoglycan Binding Extracellular Matrix Binding Extracellular Matrix Structural Constituent Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Collagen Binding Extracellular Structure Organization Extracellular Matrix Organization Extracellular Space Basement Membrane Regulation Of Cell Adhesion Heparin Binding Endodermal Cell Differentiation Acute-phase Response Response To Wounding Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development Calcium Ion Binding Acute Inflammatory Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Platelet Activation Angiogenesis Dendrite Regeneration Extracellular Vesicle Regulation Of Intracellular Signal Transduction Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Development Calcium-independent Cell-matrix Adhesion Signaling Receptor Binding Regulation Of Protein Phosphorylation Matrilin Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Monoatomic Ion Transport Oncostatin-M-mediated Signaling Pathway Cell Adhesion Regulation Of Mitochondrion Organization Regulation Of Inflammatory Response Cell Migration Regulation Of Phosphorylation Negative Regulation Of Transport
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