COL4A4

Gene Name		collagen, type IV, alpha 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basal Lamina Endoplasmic Reticulum Lumen
	Molecular Function	Extracellular Matrix Structural Constituent
	Biological Process	Axon Guidance Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Glomerular Basement Membrane Development
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-protein Interactions		12 interactors: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 TGFBI
Entrez ID		1286
HPRD ID		00360
Ensembl ID		ENSG00000081052
Uniprot IDs		P53420
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Response To Wounding Wound Healing Endodermal Cell Differentiation Acute-phase Response Leukocyte Migration Regulation Of Cell Adhesion Peptide Cross-linking Endoderm Formation Seminal Vesicle Epithelium Development Dendrite Regeneration Anatomical Structure Morphogenesis Cell Migration Acute Inflammatory Response Cell Motility Endoderm Development Negative Regulation Of Transport Tissue Development Negative Regulation Of Ion Transport Mating Plug Formation Blood Coagulation Hemostasis Response To External Stimulus Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein System Development Formation Of Primary Germ Layer Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Receptor Binding Calcium-independent Cell-matrix Adhesion Cell Adhesion Positive Regulation Of Keratinocyte Migration Negative Regulation Of Plasminogen Activation Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Body Fluid Levels Locomotion Immune System Process Chemotaxis Regulation Of Growth Reproductive Process Nervous System Development Multicellular Organismal Development Response To Stress Gastrulation Platelet Activation Cell Activation Negative Regulation Of Platelet Aggregation Tyrosine Phosphorylation Of STAT Protein
Tagcloud ?		alport basement clarification classic diagnostics families focal fsgs gbm glomerulosclerosis hematuria hereditary heterozygous histologic illustrates inconsistent inherited interpretation nephritis nephropathy nephrotic pathognomonic predominant proteinuria segmental segregated thin variants