COL4A4 and SERPINE2

Number of citations of the paper that reports this interaction (PubMedID 8006028)
0

Data Source:
HPRD (in vivo)

		COL4A4	SERPINE2
Description		collagen type IV alpha 4 chain	serpin family E member 2
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Extracellular Space Cytosol Extracellular Matrix Platelet Alpha Granule Neuromuscular Junction Extracellular Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Molecular Adaptor Activity	Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Peptidase Inhibitor Activity
	Biological Process	Glomerular Basement Membrane Development	Nervous System Development Blood Coagulation Negative Regulation Of Cell Population Proliferation Response To Wounding Negative Regulation Of Platelet Activation Negative Regulation Of Plasminogen Activation Negative Regulation Of Sodium Ion Transport Negative Regulation Of Protein Processing Cerebellar Granular Layer Morphogenesis Cell Differentiation Protein Catabolic Process Platelet Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Cell Migration Secretion By Cell Secretory Granule Organization Negative Regulation Of Protein Catabolic Process Mating Plug Formation Negative Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Regulation Of Timing Of Cell Differentiation Positive Regulation Of Astrocyte Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Innervation Seminal Vesicle Epithelium Development Negative Regulation Of Platelet Aggregation
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Dissolution of Fibrin Clot
Drugs		TRC093
Diseases		Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Birth weight ( 31043758) Body mass index ( 25673413 28270201) Coronary artery disease ( 29212778) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Macular thickness ( 30535121) Systolic blood pressure ( 30578418) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189)	Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) ( 23648065) Blood protein levels ( 30072576) Cerebrospinal T-tau levels ( 28247064) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Height ( 20881960 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Mean platelet volume ( 27863252 32888494) Platelet-derived growth factor BB levels ( 27989323)
Interacting Genes		13 interacting genes: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 MTDH OSM SAA1 SERPINE2 TGFBI	9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ETS2 F2 FAM9B
Entrez ID		1286	5270
HPRD ID		00360	01510
Ensembl ID		ENSG00000081052	ENSG00000135919
Uniprot IDs		P53420	P07093
PDB IDs		5NB1 6WKU	4DY0 4DY7
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Glycosaminoglycan Binding Extracellular Matrix Binding Extracellular Matrix Structural Constituent Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Collagen Binding Extracellular Structure Organization Extracellular Matrix Organization Extracellular Space Basement Membrane Regulation Of Cell Adhesion Heparin Binding Endodermal Cell Differentiation Acute-phase Response Response To Wounding Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development Calcium Ion Binding Acute Inflammatory Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Platelet Activation Angiogenesis Dendrite Regeneration Extracellular Vesicle Regulation Of Intracellular Signal Transduction Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Development Calcium-independent Cell-matrix Adhesion Signaling Receptor Binding Regulation Of Protein Phosphorylation Matrilin Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Monoatomic Ion Transport Oncostatin-M-mediated Signaling Pathway Cell Adhesion Regulation Of Mitochondrion Organization Regulation Of Inflammatory Response Cell Migration Regulation Of Phosphorylation Negative Regulation Of Transport	Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Extracellular Matrix Structural Constituent Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Extracellular Region Glomerular Basement Membrane Development Cell Surface Receptor Signaling Pathway Neuromuscular Junction Development Cellular Response To Amino Acid Stimulus Ectodermal Cell Fate Commitment Response To Amino Acid Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Thrombospondin Receptor Activity Neutrophil-mediated Killing Of Gram-negative Bacterium Retinal Blood Vessel Morphogenesis Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
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