DMBX1 and OTX2

Number of citations of the paper that reports this interaction (PMID 15890343)
1

Data Source:
HPRD (in vitro)

		DMBX1	OTX2
Gene Name		diencephalon/mesencephalon homeobox 1	orthodenticle homeobox 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus Cytoplasm Growth Cone Protein Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Eukaryotic Initiation Factor 4E Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Central Nervous System Development Brain Development Adult Feeding Behavior Adult Locomotory Behavior Negative Regulation Of Transcription, DNA-templated Developmental Growth	Cell Fate Specification Protein Complex Assembly Axon Guidance Endoderm Development Regulation Of Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Metencephalon Development Forebrain Development Midbrain Development Somite Rostral/caudal Axis Specification Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Eye Photoreceptor Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Determination Diencephalon Morphogenesis Primitive Streak Formation Positive Regulation Of Gastrulation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: OTX2 UBC	9 interactors: APP ATXN1 CDK4 DMBX1 FOXA2 LHX1 MITF TLE4 ZDHHC17
Entrez ID		127343	5015
HPRD ID		07593	07190
Ensembl ID		ENSG00000197587	ENSG00000165588
Uniprot IDs		Q8NFW5	F1T0C9 F1T0D0 F1T0D1 P32243
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Growth Factor Stimulus Eye Photoreceptor Cell Fate Commitment Diencephalon Morphogenesis Neuron Fate Determination Positive Regulation Of Gastrulation Primitive Streak Formation Viral Protein Processing Somite Rostral/caudal Axis Specification Transcription From RNA Polymerase II Promoter Forebrain Morphogenesis Notch Receptor Processing Positive Regulation Of Transcription From RNA Polymerase II Promoter Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Positive Regulation Of Embryonic Development Regulation Of Gastrulation Positive Regulation Of Transcription, DNA-templated Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Brain Morphogenesis Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Eye Photoreceptor Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Cell Fate Determination Positive Regulation Of Gene Expression Embryonic Axis Specification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Regulation Of DNA-templated Transcription In Response To Stress Gastrulation With Mouth Forming Second DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint	Adult Locomotory Behavior Ectoderm Formation Adult Behavior Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Locomotory Behavior Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gastrulation Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Primitive Streak Formation Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Somite Rostral/caudal Axis Specification Single-organism Behavior RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Ectoderm Development Gene Expression Behavior Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Differentiation In Hindbrain Macromolecule Biosynthetic Process Positive Regulation Of Embryonic Development RNA Biosynthetic Process Signaling Regulation Of Gastrulation Cell Communication Positive Regulation Of Cellular Metabolic Process Brain Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Developmental Growth System Development Regulation Of Cell Cycle G2/M Phase Transition Head Development Regulation Of Transcription, DNA-templated Embryonic Axis Specification Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Transcription From RNA Polymerase II Promoter Gastrulation With Mouth Forming Second
Tagcloud ?			accumulate anatomical argue arise assertions atavism cartilages chondrify claim condensation disrupted disruptions dlx evolutionary hoxa hypotheses investigators jaw knockout mesenchyme mhox migrate morphogenesis played primitive reversals reversion specification sufficiently
Tagcloud (Difference) ?			accumulate anatomical argue arise assertions atavism cartilages chondrify claim condensation disrupted disruptions dlx evolutionary hoxa hypotheses investigators jaw knockout mesenchyme mhox migrate morphogenesis played primitive reversals reversion specification sufficiently
Tagcloud (Intersection) ?