CNGA2 and NHERF1

Number of citations of the paper that reports this interaction (PubMedID 14604981)
0

Data Source:
HPRD (two hybrid, in vitro)

		CNGA2	NHERF1
Description		cyclic nucleotide gated channel subunit alpha 2	NHERF family PDZ scaffold protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Intracellular Cyclic Nucleotide Activated Cation Channel Complex Golgi-associated Vesicle Membrane Cell Projection Ciliary Membrane Non-motile Cilium Membrane	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Intracellularly CAMP-activated Cation Channel Activity Intracellularly CGMP-activated Cation Channel Activity Calcium Channel Activity Calmodulin Binding CAMP Binding CGMP Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Calcium Ion Transport Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Monoatomic Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Olfactory Signaling Pathway VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases			Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS
Interacting Genes		2 interacting genes: CALM1 NHERF1	67 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 BCL10 BCL2A1 BRSK2 CDK1 CEBPA CFTR CLCN3 CNGA2 CRABP1 CTNNB1 DLGAP4 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468
Entrez ID		1260	9368
HPRD ID		08946	05406
Ensembl ID		ENSG00000183862	ENSG00000109062
Uniprot IDs		B3KXY3 Q16280	O14745
PDB IDs			1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR
Enriched GO Terms of Interacting Partners?		Sperm Midpiece Negative Regulation Of Monoatomic Ion Transport Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Organelle Localization Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Transport Vesicle Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Type 2 Metabotropic Glutamate Receptor Binding Microvillus Assembly Type 3 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Dopamine Receptor Binding Beta-2 Adrenergic Receptor Binding Renal Phosphate Ion Absorption Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of System Process Intracellular Phosphate Ion Homeostasis Import Into Cell Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Glutathione Transport Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Voltage-gated Calcium Channel Activity Titin Binding Detection Of Calcium Ion Calcium Channel Inhibitor Activity Negative Regulation Of Sodium Ion Transport Gamma-aminobutyric Acid Transport Golgi Localization Maintenance Of Cell Polarity	Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis
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