ZC3H18 and TERF2

Number of citations: 82 (PubMedID 21044950)
Data Source: BioGRID (two hybrid)

		ZC3H18	TERF2
Name		zinc finger CCCH-type containing 18	telomeric repeat binding factor 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Speck Protein-containing Complex Ribonucleoprotein Complex	Chromosome, Telomeric Region Telomere Cap Complex Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nuclear Body Axon Shelterin Complex
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Metal Ion Binding MRNA Cap Binding Complex Binding	DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Enzyme Binding Telomeric DNA Binding Protein Homodimerization Activity Protein-containing Complex Binding G-rich Strand Telomeric DNA Binding
	Biological Process	RNA Destabilization	Telomere Maintenance In Utero Embryonic Development RNA-templated DNA Biosynthetic Process Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Recombination Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric D-loop Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Senescence Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Negative Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Cellular Senescence
Pathways		Nuclear RNA decay	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
GWAS		Aspartate aminotransferase levels ( 33547301 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hair color ( 26926045 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Trunk fat mass ( 28552196 )	Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Daytime nap ( 33568662 ) Leukocyte telomere length ( 32109421 ) Logical memory (delayed recall) in normal cognition ( 29274321 ) Pulse pressure ( 30578418 )
Novel Interactors		3 novel interactors: AFG3L1P CA5A GAS8-AS1	1 novel interactors: NUTF2
Interacting Genes		2 interacting genes: TERF1 TERF2	58 interacting genes: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BARD1 BLM CCDC137 CTBP1 DDX21 DDX24 EP300 GNMT H2AX HDGFL2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NUMB NXNL1 OCM2 ORC3 ORC6 PIAS1 PIK3R3 PPM1G PRMT1 PTMA RNF113A RNF4 RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 UBE2I WDR4 WRN XRCC6 ZC3H18
Entrez ID		124245	7014
HPRD ID		11232	03610
Ensembl ID		ENSG00000158545	ENSG00000132604
Uniprot IDs		B4DTK7 E7ERS3 Q86VM9	Q15554
PDB IDs		Not available	1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C 4RQI 5WQD 5XYF 6J67 7C5D
GO Terms Enriched among Interactors		Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Shelterin Complex Telomerase Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance DNA Biosynthetic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Telomeric Loop Formation Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of DNA Metabolic Process Negative Regulation Of T-circle Formation Chromosome, Telomeric Region Negative Regulation Of Mitotic Recombination Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Chromosome Organization Ankyrin Repeat Binding Protection From Non-homologous End Joining At Telomere Regulation Of Mitotic Recombination Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Negative Regulation Of Telomere Capping Negative Regulation Of Cell Cycle Process	Nucleoplasm Nucleus DNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Damage Response Chromosome, Telomeric Region DNA Recombination Telomere Maintenance Chromatin Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Organization DNA Repair Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Recombinational Repair Cellular Response To Stress Regulation Of Primary Metabolic Process DNA Binding Regulation Of DNA Metabolic Process Double-strand Break Repair Negative Regulation Of Metabolic Process Nuclear Speck RNA Binding DNA Geometric Change Bubble DNA Binding Chromosome Organization Telomeric DNA Binding Negative Regulation Of RNA Metabolic Process Damaged DNA Binding Nuclear Telomere Cap Complex 7SK SnRNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Cellular Response To Ionizing Radiation Negative Regulation Of Macromolecule Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Metabolic Process Cytoplasm Regulation Of DNA Recombination Response To Ionizing Radiation Nucleosomal DNA Binding Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Forked DNA-dependent Helicase Activity