CCL4 and CCR1

Number of citations of the paper that reports this interaction (PMID 7594543)
15

Data Source:
HPRD (in vitro)

		CCL4	CCR1
Gene Name		chemokine (C-C motif) ligand 4	chemokine (C-C motif) receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Movement Of Cell Or Subcellular Component Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell-cell Signaling Response To Virus Response To Toxic Substance Negative Regulation By Host Of Viral Transcription Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Metabolic Process Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140)
Protein-Protein Interactions		8 interactors: ACKR2 CCL3 CCR1 CCR3 CCR5 CCR8 CXCL8 SLC30A2	20 interactors: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CREB3 GNA14 JAK1 PLP2 STAT1 STAT3 TPST1 TPST2
Entrez ID		6351	1230
HPRD ID		01657	03101
Ensembl ID			ENSG00000163823
Uniprot IDs		P13236	P32246 Q5U003
PDB IDs		1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2	1Y5D
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Cytokine-mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Locomotion Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Leukocyte Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Response To External Stimulus Cellular Ion Homeostasis Cellular Response To Organic Substance Cell Chemotaxis Metal Ion Homeostasis Cellular Chemical Homeostasis G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Leukocyte Migration Immune Response Defense Response Cellular Homeostasis Response To Organic Substance Positive Regulation Of Leukocyte Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Leukocyte Migration Chemical Homeostasis Calcium-mediated Signaling Cell Surface Receptor Signaling Pathway Sarcoplasmic Reticulum Calcium Ion Transport Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Dendritic Cell Chemotaxis Regulation Of Chemotaxis Second-messenger-mediated Signaling Immune System Process Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Neutrophil Activation Regulation Of Ion Homeostasis Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Response To Cholesterol Regulation Of Behavior Dendritic Cell Migration	Cell Chemotaxis Chemotaxis Inflammatory Response Locomotion Cell Migration Cell Motility Immune Response Defense Response Response To External Stimulus Movement Of Cell Or Subcellular Component Monocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Cellular Calcium Ion Homeostasis Immune System Process Calcium Ion Homeostasis Positive Regulation Of Leukocyte Migration Response To Stress Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Chemical Homeostasis Cellular Metal Ion Homeostasis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Chemotaxis Regulation Of Behavior Positive Regulation Of Cellular Component Movement Ion Homeostasis Positive Regulation Of Locomotion Cellular Response To Stimulus Positive Regulation Of Calcium Ion Transport Regulation Of Cell Migration Cell-cell Signaling Regulation Of Cell Motility Leukocyte Chemotaxis Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Eosinophil Chemotaxis Regulation Of Locomotion Homeostatic Process Regulation Of Cellular Component Movement Eosinophil Migration Cellular Homeostasis
Tagcloud ?		acetyltransferase boxes cat chloramphenicol coinciding construct constructs fibrogenesis fibrogenic fibrotic hepatic igfiir inducer latent livers m6p mannose mutagenized p75 participating participation quiescent reporter repressor residing stellate stimulant tetrachloride transcript	7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		acetyltransferase boxes cat chloramphenicol coinciding construct constructs fibrogenesis fibrogenic fibrotic hepatic igfiir inducer latent livers m6p mannose mutagenized p75 participating participation quiescent reporter repressor residing stellate stimulant tetrachloride transcript	7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?