CCL4 and CXCL8

Number of citations of the paper that reports this interaction (PMID 8077676)
15

Data Source:
HPRD (in vitro)

		CCL4	CXCL8
Gene Name		chemokine (C-C motif) ligand 4	chemokine (C-X-C motif) ligand 8
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding	Interleukin-8 Receptor Binding Protein Binding Chemokine Activity
	Biological Process	Movement Of Cell Or Subcellular Component Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell-cell Signaling Response To Virus Response To Toxic Substance Negative Regulation By Host Of Viral Transcription Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis	Angiogenesis Response To Molecule Of Bacterial Origin Movement Of Cell Or Subcellular Component Chemotaxis Inflammatory Response Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Receptor Internalization Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Cellular Senescence ATF4 activates genes Senescence-Associated Secretory Phenotype (SASP) GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACKR2 CCL3 CCR1 CCR3 CCR5 CCR8 CXCL8 SLC30A2	18 interactors: ACKR1 ARFGAP3 BAG6 CCL4 CCL5 CSNK2A1 CTSL CXCR1 CXCR2 EP300 GNAI2 IL12A MMP9 PF4 POMGNT1 SDC1 SGTA WASF1
Entrez ID		6351	3576
HPRD ID		01657	00909
Ensembl ID			ENSG00000169429
Uniprot IDs		P13236	P10145
PDB IDs		1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2	1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Cytokine-mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Locomotion Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Leukocyte Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Response To External Stimulus Cellular Ion Homeostasis Cellular Response To Organic Substance Cell Chemotaxis Metal Ion Homeostasis Cellular Chemical Homeostasis G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Leukocyte Migration Immune Response Defense Response Cellular Homeostasis Response To Organic Substance Positive Regulation Of Leukocyte Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Leukocyte Migration Chemical Homeostasis Calcium-mediated Signaling Cell Surface Receptor Signaling Pathway Sarcoplasmic Reticulum Calcium Ion Transport Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Dendritic Cell Chemotaxis Regulation Of Chemotaxis Second-messenger-mediated Signaling Immune System Process Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Neutrophil Activation Regulation Of Ion Homeostasis Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Response To Cholesterol Regulation Of Behavior Dendritic Cell Migration	Chemokine-mediated Signaling Pathway Defense Response Inflammatory Response Signal Transduction Cell Chemotaxis Dendritic Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Signaling Response To External Stimulus Cell Communication Movement Of Cell Or Subcellular Component Positive Regulation Of Leukocyte Migration Leukocyte Migration Interleukin-8-mediated Signaling Pathway Response To Stress Immune System Process Dendritic Cell Migration Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cell Migration Cellular Response To Stimulus Locomotion Interaction With Symbiont Positive Regulation Of Behavior Cell Motility Cell Surface Receptor Signaling Pathway Regulation Of Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Behavior Cytokine-mediated Signaling Pathway Regulation Of Viral Transcription Immune Response Response To Stimulus Negative Regulation By Host Of Viral Transcription Response To Organic Substance Positive Regulation Of Immune System Process Regulation Of Apoptotic Process Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Regulation Of Cell Proliferation Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Cell Death Regulation Of Cell Motility Regulation Of Locomotion
Tagcloud ?		acetyltransferase boxes cat chloramphenicol coinciding construct constructs fibrogenesis fibrogenic fibrotic hepatic igfiir inducer latent livers m6p mannose mutagenized p75 participating participation quiescent reporter repressor residing stellate stimulant tetrachloride transcript
Tagcloud (Difference) ?		acetyltransferase boxes cat chloramphenicol coinciding construct constructs fibrogenesis fibrogenic fibrotic hepatic igfiir inducer latent livers m6p mannose mutagenized p75 participating participation quiescent reporter repressor residing stellate stimulant tetrachloride transcript
Tagcloud (Intersection) ?