CCL4 and TAS2R5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCL4	TAS2R5
Description		C-C motif chemokine ligand 4	taste 2 receptor member 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Protein Binding Taste Receptor Activity Bitter Taste Receptor Activity
	Biological Process	Chemotaxis Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Cell Migration Host-mediated Suppression Of Viral Transcription Eosinophil Chemotaxis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Chemotaxis	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Signal Transduction G Protein-coupled Receptor Signaling Pathway Chemosensory Behavior Sensory Perception Of Taste
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Sensory perception of sweet, bitter, and umami (glutamate) taste Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Anorexia nervosa ( 23568457) Late-onset Alzheimer's disease ( 27770636)
Interacting Genes		26 interacting genes: ACKR2 ARL13B CCL3 CCR1 CCR3 CCR5 CCR8 CNR2 CXCL8 GJA8 GPR152 GPRC5D MARCHF2 MRM1 SLC10A6 SLC18A1 SLC30A2 SLC30A8 SLC7A1 TAS2R5 TIMMDC1 TMEM14B TMEM179B TMEM31 TMEM86B UNC93A	6 interacting genes: CCL4 RTP2 SFT2D2 SLC30A2 TMEM187 VAMP5
Entrez ID		6351	54429
HPRD ID		01657	05453
Ensembl ID		ENSG00000275302	ENSG00000127366
Uniprot IDs		P13236	A4D1U0 Q502V5 Q9NYW4
PDB IDs		1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2 4RAL
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cell Chemotaxis Chemotaxis Chemokine-mediated Signaling Pathway Locomotion G Protein-coupled Receptor Activity Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway Membrane Plasma Membrane Chemokine (C-C Motif) Ligand 5 Binding Leukocyte Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Migration Immune Response Inflammatory Response Response To Cytokine Response To Peptide Zinc:proton Antiporter Activity Cell Motility Leukocyte Migration Cytokine-mediated Signaling Pathway Intracellular Signaling Cassette Cellular Response To Cytokine Stimulus Transport Vesicle Membrane Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Zinc Ion Import Into Organelle Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Monoatomic Cation Transport Defense Response External Side Of Plasma Membrane Sarcoplasmic Reticulum Calcium Ion Transport Dendritic Cell Chemotaxis Metal Ion Transport Transmembrane Transport Response To Interleukin-1 Monoatomic Cation Transmembrane Transporter Activity Import Into Cell Negative Regulation Of Bone Mineralization Positive Regulation Of Leukocyte Chemotaxis Immune System Process Monoatomic Ion Transport Positive Regulation Of Neuroinflammatory Response Secretory Granule Membrane Monocyte Chemotaxis Zinc Ion Transmembrane Transporter Activity Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity	Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle CCR1 Chemokine Receptor Binding Positive Regulation Of Natural Killer Cell Chemotaxis Zinc:proton Antiporter Activity Zinc Ion Import Into Lysosome Zinc Export Across Plasma Membrane Late Endosome Establishment Of Protein Localization To Membrane Olfactory Receptor Binding CCR5 Chemokine Receptor Binding Vacuolar Transmembrane Transport Zinc Ion Import Into Organelle Secretory Vesicle Endomembrane System
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