CCL28 and CCR3

Number of citations of the paper that reports this interaction (PMID 10975800)
40

Data Source:
HPRD (in vivo)

		CCL28	CCR3
Gene Name		chemokine (C-C motif) ligand 28	chemokine (C-C motif) receptor 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Chemokine Activity	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Chemotaxis Immune Response Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Cell Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Cellular Defense Response Cell Adhesion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140) Monocyte chemoattractant protein-1 ( 23017229) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: ACKR2 CCR10 CCR3 DDI1 PSMA3 STUB1	19 interactors: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		56477	1232
HPRD ID		05577	03167
Ensembl ID			ENSG00000183625
Uniprot IDs		A0N0Q3 Q9NRJ3	P51677 Q8TDP4 Q8TDP5
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Neutrophil Activation Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Cytokine Stimulus Chemotaxis Response To Stress Positive Regulation Of Protein Ubiquitination Response To Cytokine Positive Regulation Of Chaperone-mediated Protein Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Polyubiquitination Cytosolic Calcium Ion Homeostasis Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Response To Organic Substance Ubiquitin-dependent SMAD Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Calcium Ion Homeostasis Locomotion Signal Transduction Regulation Of Glucocorticoid Metabolic Process Defense Response Receptor-mediated Endocytosis Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Cell Surface Receptor Signaling Pathway Signaling Regulation Of Protein Catabolic Process Cell Communication Response To Misfolded Protein Cellular Metal Ion Homeostasis Proteolysis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Leukocyte Activation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Chemical Homeostasis	Cell Chemotaxis Cell Migration Cell Motility Chemotaxis Locomotion Immune Response Movement Of Cell Or Subcellular Component Inflammatory Response Response To External Stimulus Immune System Process Leukocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Leukocyte Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Eosinophil Chemotaxis Positive Regulation Of Leukocyte Migration Defense Response Eosinophil Migration Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cellular Component Movement Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Granulocyte Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Regulation Of Lymphocyte Migration Cellular Metal Ion Homeostasis Regulation Of Cell Shape Cellular Cation Homeostasis Cell-cell Signaling Cellular Ion Homeostasis Positive Regulation Of Calcium Ion Transport Metal Ion Homeostasis Regulation Of Behavior Response To Other Organism Lymphocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Response To Biotic Stimulus T Cell Migration Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Immune System Process Regulation Of Immune System Process
Tagcloud ?		17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1	basophil basophils c5a ccr2 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Difference) ?		17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1	basophil basophils c5a ccr2 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Intersection) ?