PRAF2 and CLEC10A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRAF2	CLEC10A
Description		PRA1 domain family member 2	C-type lectin domain containing 10A
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Endosome Membrane Membrane Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Lysosome Lysosomal Membrane Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Early Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Fucose Binding
	Biological Process	Protein Transport L-glutamate Transmembrane Transport	Adaptive Immune Response Immune System Process Endocytosis Immune Response Innate Immune Response
Pathways			Dectin-2 family
Drugs
Diseases
GWAS			Carotid intima media thickness x smoking interaction ( 32117412) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Liver enzyme levels (alkaline phosphatase) ( 33972514) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		27 interacting genes: ABHD16A ADGRD1 AGR3 AQP6 ARL6IP5 CCR5 CD79A CFTR CIAO2A CLEC10A EBAG9 GJA5 GJA8 GPR152 HIBADH HSD17B11 MCEMP1 MIEF1 NDRG4 REEP4 RETREG3 RNF5 SLC10A6 TLCD4 TMEM14B TMX2 ZDHHC15	26 interacting genes: ACSF2 ADIPOQ APOD BET1 C3orf52 CFTR CLN6 FMO3 FXYD6 GIMAP1 MALL NAPB PEX16 PRAF2 SEC22A SLC38A7 SMCO4 SNCA TMEM218 TNF TRARG1 TSPO UNC50 VSTM1 ZDHHC15 ZFPL1
Entrez ID		11230	10462
HPRD ID		06596	12076
Ensembl ID		ENSG00000243279	ENSG00000132514
Uniprot IDs		O60831	J3KR22 Q8IUN9
PDB IDs			6PUV 6PY1 6W12 6XIY
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Nitrate Transmembrane Transporter Activity Protein Binding Fluid Transport Transmembrane Transport Water Transport Endoplasmic Reticulum Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Embryonic Heart Tube Development Gap Junction Channel Activity Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Connexin Complex 3-hydroxyisobutyrate Dehydrogenase Activity Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Positive Regulation Of Neuron Projection Development	Membrane Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Endoplasmic Reticulum Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Protein Localization To Membrane Regulation Of Lipid Metabolic Process Negative Regulation Of Secretion Cellular Response To Epinephrine Stimulus Intracellular Protein Localization Positive Regulation Of Monoatomic Ion Transport Response To Epinephrine Regulation Of Chemokine Production Negative Regulation Of Transport Axon Regeneration Establishment Of Protein Localization Regulation Of Oxidative Phosphorylation Regulation Of Smooth Muscle Cell Proliferation Lipid Metabolic Process Glucose Metabolic Process Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Cytokine Production Negative Regulation Of Lipoprotein Lipid Oxidation Neuron Projection Regeneration Regeneration Small Molecule Metabolic Process Regulation Of Hormone Secretion Response To Xenobiotic Stimulus Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Secretion By Cell Positive Regulation Of Transport Negative Regulation Of Secretion By Cell Positive Regulation Of Glial Cell Proliferation Regulation Of Small Molecule Metabolic Process Negative Regulation Of Corticosterone Secretion Negative Regulation Of Lipid Transport Chemical Homeostasis Response To Alcohol Positive Regulation Of Monoatomic Ion Transmembrane Transport Endoplasmic Reticulum Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Albendazole Monooxygenase Activity Response To Desipramine Regulation Of Aerobic Respiration Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity
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