PRAF2 and ADGRD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRAF2	ADGRD1
Description		PRA1 domain family member 2	adhesion G protein-coupled receptor D1
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Endosome Membrane Membrane Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Nucleoplasm Cytosol Plasma Membrane Membrane Nuclear Speck
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Protein Transport L-glutamate Transmembrane Transport	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Skeletal Muscle Contraction
Pathways
Drugs			Onapristone
Diseases
GWAS			Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549)
Interacting Genes		27 interacting genes: ABHD16A ADGRD1 AGR3 AQP6 ARL6IP5 CCR5 CD79A CFTR CIAO2A CLEC10A EBAG9 GJA5 GJA8 GPR152 HIBADH HSD17B11 MCEMP1 MIEF1 NDRG4 REEP4 RETREG3 RNF5 SLC10A6 TLCD4 TMEM14B TMX2 ZDHHC15	1 interacting genes: PRAF2
Entrez ID		11230	283383
HPRD ID		06596	17061
Ensembl ID		ENSG00000243279	ENSG00000111452
Uniprot IDs		O60831	Q6QNK2
PDB IDs			7EPT 7WU2 8X9S 8X9T 8X9U 9IV1 9IV2
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Nitrate Transmembrane Transporter Activity Protein Binding Fluid Transport Transmembrane Transport Water Transport Endoplasmic Reticulum Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Embryonic Heart Tube Development Gap Junction Channel Activity Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Connexin Complex 3-hydroxyisobutyrate Dehydrogenase Activity Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Positive Regulation Of Neuron Projection Development	L-glutamate Transmembrane Transport Amino Acid Transport Organic Acid Transmembrane Transport L-glutamate Import Amino Acid Transmembrane Transport L-alpha-amino Acid Transmembrane Transport Acidic Amino Acid Transport L-amino Acid Transport Carboxylic Acid Transmembrane Transport GABA-ergic Synapse Dicarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Presynapse Postsynapse Endosome Membrane Organic Anion Transport
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