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PRAF2 and CCR5
Number of citations of the paper that reports this interaction (PubMedID
15757671
)
0
Data Source:
HPRD
(two hybrid, in vivo)
PRAF2
CCR5
Description
PRA1 domain family member 2
C-C motif chemokine receptor 5
Image
No pdb structure
GO Annotations
Cellular Component
Endosome
Endosome Membrane
Membrane
Presynapse
Postsynapse
Glutamatergic Synapse
GABA-ergic Synapse
Cytoplasm
Endosome
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Molecular Function
Protein Binding
Virus Receptor Activity
Actin Binding
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
G Protein-coupled Receptor Activity
Chemokine Receptor Activity
Protein Binding
Coreceptor Activity
C-C Chemokine Receptor Activity
C-C Chemokine Binding
Identical Protein Binding
Chemokine (C-C Motif) Ligand 5 Binding
Biological Process
Protein Transport
L-glutamate Transmembrane Transport
MAPK Cascade
Dendritic Cell Chemotaxis
Calcium Ion Transport
Apoptotic Process
Chemotaxis
Defense Response
Inflammatory Response
Immune Response
Cellular Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Calcium-mediated Signaling
Signaling
Symbiont Entry Into Host Cell
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Response To Cholesterol
Cellular Response To Lipopolysaccharide
Cellular Response To Cytokine Stimulus
Negative Regulation Of Macrophage Apoptotic Process
Pathways
Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Drugs
Maraviroc
AMD-070
CCR5 mAb
Leronlimab
Aplaviroc
Vicriviroc
Ibalizumab
INCB-9471
Diseases
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Celiac disease (
20190752
)
Cerebrospinal fluid levels of Alzheimer's disease-related proteins (
25340798
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
26192919
)
Type 1 diabetes (
25751624
)
Ulcerative colitis (
26192919
28067908
)
Interacting Genes
27 interacting genes:
ABHD16A
ADGRD1
AGR3
AQP6
ARL6IP5
CCR5
CD79A
CFTR
CIAO2A
CLEC10A
EBAG9
GJA5
GJA8
GPR152
HIBADH
HSD17B11
MCEMP1
MIEF1
NDRG4
REEP4
RETREG3
RNF5
SLC10A6
TLCD4
TMEM14B
TMX2
ZDHHC15
43 interacting genes:
AFP
ARL6IP5
ARRB1
CCL11
CCL13
CCL14
CCL16
CCL2
CCL3
CCL3L1
CCL3L3
CCL4
CCL5
CCL7
CCL8
CD4
CST9L
CTBP2
CXCR4
DNM2
EMP1
ETV5
GNAI1
GNAI2
GNAI3
GNAO1
GNAQ
GRK2
GRK3
IL24
JAK1
JAK2
LCK
ORM1
PRAF2
PSMA5
PTK2
PTK2B
SLC20A2
STAT1
STAT3
STAT5A
TXK
Entrez ID
11230
1234
HPRD ID
06596
03223
Ensembl ID
ENSG00000243279
ENSG00000160791
Uniprot IDs
O60831
P51681
Q38L21
PDB IDs
2L87
2MZX
2RLL
2RRS
4MBS
5UIW
5YD3
5YD4
5YD5
5YY4
6FGP
6MEO
6MET
7F1Q
7F1R
7F1S
7NJZ
7NW3
7O7F
8AS2
8AS3
Enriched GO Terms of Interacting Partners
?
Membrane
Endoplasmic Reticulum
Nitrate Transmembrane Transporter Activity
Protein Binding
Fluid Transport
Transmembrane Transport
Water Transport
Endoplasmic Reticulum Membrane
Intracellularly ATP-gated Chloride Channel Activity
Positive Regulation Of Voltage-gated Chloride Channel Activity
Sec61 Translocon Complex Binding
Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling
Mitral Valve Development
Septum Primum Development
Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling
Gap Junction
Atrial Ventricular Junction Remodeling
Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling
Embryonic Heart Tube Development
Gap Junction Channel Activity
Positive Regulation Of Cell Communication By Chemical Coupling
Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling
Vasomotion
Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling
Regulation Of Purkinje Myocyte Action Potential
Connexin Complex
3-hydroxyisobutyrate Dehydrogenase Activity
Endoplasmic Reticulum Tubular Network
Endoplasmic Reticulum Tubular Network Organization
Sodium-dependent Organic Anion Transmembrane Transporter Activity
Sodium-dependent Organic Anion Transport
Positive Regulation Of Neuron Projection Development
Chemokine-mediated Signaling Pathway
CCR Chemokine Receptor Binding
Cytokine-mediated Signaling Pathway
Chemokine Activity
G Protein-coupled Receptor Signaling Pathway
Eosinophil Chemotaxis
Eosinophil Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Antimicrobial Humoral Response
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Cell Chemotaxis
Cytokine Activity
CCR5 Chemokine Receptor Binding
Immune System Process
Immune Response
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Migration
Humoral Immune Response
Regulation Of Cell Motility
Signal Transduction
Regulation Of Locomotion
Granulocyte Chemotaxis
Leukocyte Migration
Chemotaxis
Granulocyte Migration
Defense Response
Cell Migration
Leukocyte Chemotaxis
Inflammatory Response
Locomotion
Response To Other Organism
Response To External Biotic Stimulus
Cell Motility
Regulation Of Lymphocyte Chemotaxis
Myeloid Leukocyte Migration
Defense Response To Symbiont
Positive Regulation Of Natural Killer Cell Chemotaxis
Defense Response To Other Organism
Guanyl Nucleotide Binding
CCR1 Chemokine Receptor Binding
G Protein-coupled Receptor Binding
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Lymphocyte Chemotaxis
Cell Surface Receptor Signaling Pathway Via STAT
Non-membrane Spanning Protein Tyrosine Kinase Activity
G-protein Beta/gamma-subunit Complex Binding
Protein Kinase Activity
Interleukin-9-mediated Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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