CMA1 and EDN3

Number of citations of the paper that reports this interaction (PMID 9257865)
16

Data Source:
HPRD (in vitro)

		CMA1	EDN3
Gene Name		chymase 1, mast cell	endothelin 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptide Binding	Receptor Binding Hormone Activity
	Biological Process	Angiotensin Maturation Proteolysis Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Midbrain Development Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Interleukin-1 Beta Biosynthetic Process Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Blood Circulation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Neutrophil Chemotaxis Vasoconstriction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Regulation Of Developmental Pigmentation Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways		Signaling by SCF-KIT Peptide hormone metabolism Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Degradation of the extracellular matrix	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Phenylalanylmethane Benzylsulfinic Acid 2-(N-Morpholino)-Ethanesulfonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID
Diseases
GWAS			Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 19430479 21909115) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		10 interactors: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3	5 interactors: CMA1 CTSE EDNRA EDNRB KEL
Entrez ID		1215	1908
HPRD ID		00346	00570
Ensembl ID		ENSG00000092009	ENSG00000124205
Uniprot IDs		P23946 Q4FEB3	P14138 Q4FAT2
PDB IDs		1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69
Enriched GO Terms of Interacting Partners?		Vascular Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vasoconstriction Positive Regulation Of Oxidoreductase Activity Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Regulation Of Vasoconstriction Smooth Muscle Contraction Leukocyte Migration Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Oxidoreductase Activity Muscle System Process Inositol Phosphate-mediated Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Heart Contraction Second-messenger-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Cell Migration Regulation Of Cell Proliferation Regulation Of Catalytic Activity Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cell Motility Positive Regulation Of Immune System Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Protein Kinase Activity Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Kinase Activity Neutrophil Chemotaxis Neutrophil Migration Response To Mechanical Stimulus Positive Regulation Of MAP Kinase Activity Muscle Contraction Granulocyte Chemotaxis Positive Regulation Of Transferase Activity Regulation Of Nitric Oxide Biosynthetic Process Intracellular Signal Transduction Regulation Of Cell Migration	Vasoconstriction Endothelin Receptor Signaling Pathway Blood Circulation Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Chemical Homeostasis Enteric Nervous System Development Vascular Smooth Muscle Contraction Cellular Homeostasis Regulation Of Blood Pressure Chemical Homeostasis Negative Regulation Of CAMP Biosynthetic Process Regulation Of Inflammatory Response Negative Regulation Of CAMP Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Nucleotide Metabolic Process Autonomic Nervous System Development Cellular Metal Ion Homeostasis Homeostatic Process Regulation Of Adenylate Cyclase Activity Cellular Cation Homeostasis Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Ion Homeostasis Regulation Of Cyclase Activity Metal Ion Homeostasis Neural Crest Cell Development Neural Crest Cell Differentiation Ion Homeostasis Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Renal System Process Regulation Of CAMP Metabolic Process Enteric Smooth Muscle Cell Differentiation Interleukin-1 Beta Biosynthetic Process Mesenchymal Cell Development Mesenchymal Cell Differentiation Posterior Midgut Development Nervous System Development Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cytosolic Calcium Ion Homeostasis Smooth Muscle Cell Proliferation Negative Regulation Of Neuron Maturation Mesenchyme Development Vein Smooth Muscle Contraction Fibroblast Proliferation Penile Erection Muscle Contraction
Tagcloud ?		a8 a9 aldehyde aldh3a1 beta4 biglycan chymase conjunctiva conjunctival fibrovascular gelsolin genechip immunofluorescent infiltrates itraq member1 pterygium rab10 s100 s100a8 s100a9 sawdust serpin serpina1 stringent thymosin uninvolved vim wing	agouti albinism asip atf1 delta25 dopachrome edn1 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		a8 a9 aldehyde aldh3a1 beta4 biglycan chymase conjunctiva conjunctival fibrovascular gelsolin genechip immunofluorescent infiltrates itraq member1 pterygium rab10 s100 s100a8 s100a9 sawdust serpin serpina1 stringent thymosin uninvolved vim wing	agouti albinism asip atf1 delta25 dopachrome edn1 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?