CMA1 and IL1B

Number of citations of the paper that reports this interaction (PubMedID 1919436)
20

Data Source:
BioGRID (enzymatic study)

		CMA1	IL1B
Description		chymase 1	interleukin 1 beta
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Extracellular Matrix Cytoplasmic Ribonucleoprotein Granule	Extracellular Region Extracellular Space Cytoplasm Lysosome Cytosol Secretory Granule Vesicle
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Peptide Binding	Cytokine Activity Interleukin-1 Receptor Binding Integrin Binding Protein Binding Protein Domain Specific Binding Receptor Ligand Activity
	Biological Process	Angiotensin Maturation Proteolysis Peptide Metabolic Process Protein Processing Extracellular Matrix Disassembly Protein Catabolic Process Midbrain Development Basement Membrane Disassembly Positive Regulation Of Angiogenesis Regulation Of Inflammatory Response Protein Maturation Cellular Response To Glucose Stimulus Cytokine Precursor Processing	Fever Generation Positive Regulation Of Cytokine Production Positive Regulation Of T Cell Mediated Immunity Apoptotic Process Inflammatory Response Immune Response Signal Transduction JNK Cascade Cell-cell Signaling Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Carbohydrate Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of D-glucose Transmembrane Transport Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Hyaluronan Biosynthetic Process Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Response To ATP Positive Regulation Of Heterotypic Cell-cell Adhesion Ectopic Germ Cell Programmed Cell Death Positive Regulation Of T Cell Proliferation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Complement Activation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Astrocyte Activation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Negative Regulation Of Synaptic Transmission Defense Response To Gram-positive Bacterium Leukocyte Migration Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Adiponectin Secretion Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Xenobiotic Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Interleukin-17 Positive Regulation Of Neuroinflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Regulation Of Establishment Of Endothelial Barrier Regulation Of Secretion By Cell Negative Regulation Of Gap Junction Assembly Positive Regulation Of Tight Junction Disassembly Positive Regulation Of T-helper 1 Cell Cytokine Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by SCF-KIT Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins	Interleukin-1 processing Pyroptosis CLEC7A/inflammasome pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage
Drugs		Benzylsulfonic acid 2-(N-morpholino)ethanesulfonic acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID	Donepezil Minocycline VP025 Gallium nitrate Talmapimod Etiprednol dicloacetate VX-702 VX-765 Andrographolide Canakinumab Rilonacept Foreskin keratinocyte (neonatal) Binimetinib Gevokizumab Dilmapimod
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Birth weight ( 31043758) Dysmenorrheic pain severity ( 29855537) Gestational age at birth (child effect) ( 31477735) Post-term birth ( 31477735)
Interacting Genes		10 interacting genes: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3	17 interacting genes: A2M ADRB2 APP CASP1 CASP4 CMA1 EGR1 FBXL2 FYN IL1R1 IL1R2 IL1RAP LYN MMP2 NEDD4 PRTN3 SP1
Entrez ID		1215	3553
HPRD ID		00346	00985
Ensembl ID		ENSG00000092009	ENSG00000125538
Uniprot IDs		P23946 Q4FEB3	P01584
PDB IDs		1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69 4KP0 5YJM 5YJP 7H60 7H61 7H62 7H63 7H64 7H65 7H66 7H67 7H68 7H69 7H6A 7H6B 7H6C 7H6D 7H6E 7H6F 7H6I 9GBH 9GC1 9GC9 9GCC 9GCD	1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5BVP 5I1B 5MVZ 5R7W 5R85 5R86 5R87 5R88 5R89 5R8A 5R8B 5R8C 5R8D 5R8E 5R8F 5R8G 5R8H 5R8I 5R8J 5R8K 5R8L 5R8M 5R8N 5R8O 5R8P 5R8Q 6I1B 6Y8I 6Y8M 7CHY 7CHZ 7I1B 7Z4T 8C3U 8RYK 8RYS 8RZB 9ILB
Enriched GO Terms of Interacting Partners?		Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Vein Smooth Muscle Contraction Leukocyte Migration Vasoconstriction Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Locomotion Myeloid Leukocyte Migration Regulation Of Systemic Arterial Blood Pressure Regulation Of Locomotion Positive Regulation Of Prostaglandin Biosynthetic Process Artery Smooth Muscle Contraction Neutrophil Chemotaxis Tonic Smooth Muscle Contraction Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Regulation Of Prostaglandin Biosynthetic Process Regulation Of Vasoconstriction Neutrophil Migration Granulocyte Chemotaxis Vascular Associated Smooth Muscle Contraction Granulocyte Migration Positive Regulation Of Fatty Acid Biosynthetic Process Hormone Activity Positive Regulation Of Heart Rate Positive Regulation Of Cellular Component Organization Circulatory System Process Regulation Of Lipid Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Lipid Metabolic Process Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Heart Contraction Positive Regulation Of Fatty Acid Metabolic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Small Molecule Metabolic Process Extracellular Region Regulation Of Blood Pressure Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Axon Extension Positive Regulation Of Muscle Contraction System Process Extracellular Space Cell Migration	Enzyme Binding Regulation Of Inflammatory Response Regulation Of Defense Response Cellular Response To Oxygen-containing Compound Response To Amyloid-beta Cytokine Precursor Processing Interleukin-1-mediated Signaling Pathway Interleukin-1 Receptor Activity Immune System Process Interleukin-1 Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Proteolysis Cytokine-mediated Signaling Pathway Regulation Of Cell Communication Cellular Response To Amyloid-beta Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Response To Stress Protein Processing Positive Regulation Of Signal Transduction Immune Response Positive Regulation Of Multicellular Organismal Process Endopeptidase Activity Membrane Raft Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ephrin Receptor Binding Protein Metabolic Process Peptidase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Neuron Apoptotic Process Regulation Of Interleukin-1 Production Positive Regulation Of Intracellular Signal Transduction Collagen Catabolic Process Growth Factor Receptor Binding Signaling Receptor Ligand Precursor Processing Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Region Protein Maturation NLRP1 Inflammasome Complex Extracellular Matrix Disassembly Serine-type Endopeptidase Activity Glutamate Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Metal Ion Transport Heparan Sulfate Binding
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