EDN3 and CTSE

Number of citations: 0 (PubMedID 2226872)
Data Source: HPRD (in vitro)

		EDN3	CTSE
Name		endothelin 3	cathepsin E
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Endosome
	Molecular Function	Signaling Receptor Binding Hormone Activity Endothelin B Receptor Binding	Aspartic-type Endopeptidase Activity Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Axon Guidance Blood Circulation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Gene Expression Intracellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Regulation Of Cell Migration Neutrophil Chemotaxis Neuron Projection Development Vasoconstriction Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Hormone Secretion Regulation Of Developmental Pigmentation Axon Extension Establishment Of Localization In Cell Potassium Ion Transmembrane Transport Blood Vessel Diameter Maintenance Positive Regulation Of Potassium Ion Transmembrane Transport	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	MHC class II antigen presentation
Diseases		Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD) Waardenburg syndrome (WS)	None
GWAS		Blood pressure ( 21909110 ) Diastolic blood pressure ( 21909115 27618452 28739976 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Hypertension ( 19430479 21909115 ) Metabolite levels ( 23823483 ) Response to diuretic therapy in hypertension ( 23753411 ) Systolic blood pressure ( 21909115 27618447 27618452 28739976 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 )	No GWAS studies recorded
Interacting Genes		5 interacting genes: CMA1 CTSE EDNRA EDNRB KEL	5 interacting genes: A2M BAG6 EDN3 EMG1 INS
Entrez ID		1908	1510
HPRD ID		00570	00294
Ensembl ID		ENSG00000124205	ENSG00000196188
Uniprot IDs		P14138 Q4FAT2	A0A7P0MPN9 B4DNU8 P14091
PDB IDs		6IGK	1TZS
GO Terms Enriched among Interactors		Vasoconstriction Endothelin Receptor Activity Renal Albumin Absorption Neural Crest Cell Migration Mesenchymal Cell Migration Renal Protein Absorption Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Developmental Pigmentation Ameboidal-type Cell Migration Blood Vessel Diameter Maintenance Regulation Of Tube Size Vascular Associated Smooth Muscle Contraction Renal Sodium Ion Absorption Renal Sodium Ion Transport Cell Differentiation Involved In Kidney Development Sodium Ion Homeostasis Establishment Of Endothelial Barrier Vascular Process In Circulatory System Chemical Homeostasis Endothelial Cell Development Renal Absorption Pigmentation Circulatory System Process Smooth Muscle Contraction Inorganic Ion Homeostasis Protein Transmembrane Transport Peptidase Activity Enteric Smooth Muscle Cell Differentiation Proteoglycan Metabolic Process Monoatomic Cation Homeostasis Homeostatic Process Monoatomic Ion Homeostasis Muscle Cell Development Canonical Wnt Signaling Pathway Regulation Of Heart Rate Intracellular Chemical Homeostasis Renal System Process Podocyte Apoptotic Process Cellular Response To Human Chorionic Gonadotropin Stimulus Posterior Midgut Development Extracellular Matrix Of Synaptic Cleft Protein Metabolic Process Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metal Ion Transport Cellular Homeostasis Basement Membrane Disassembly Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Signaling Receptor Binding Negative Regulation Of Innate Immune Response Protease Binding Interleukin-8 Binding Negative Regulation Of Complement Activation, Lectin Pathway Potassium Ion Transmembrane Transport Blood Vessel Diameter Maintenance Vein Smooth Muscle Contraction Endothelin B Receptor Binding Regulation Of Tube Size Regulation Of Nuclear Division Regulation Of Mitotic Nuclear Division Hormone Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Alpha-beta T Cell Activation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Proteolysis Receptor Ligand Activity Negative Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycogen Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Maintenance Of Unfolded Protein BAT3 Complex RRNA (pseudouridine) Methyltransferase Activity Nucleologenesis Regulation Of Immune System Process Potassium Ion Transport Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Dendritic Spine Maintenance Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Magnesium Ion Homeostasis Negative Regulation Of Respiratory Burst Nucleolus Organization Tumor Necrosis Factor Binding Interleukin-1 Binding Negative Regulation Of Feeding Behavior Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Immune Response Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Glycogen Catabolic Process Internal Peptidyl-lysine Acetylation Positive Regulation Of Respiratory Burst Nitric Oxide-cGMP-mediated Signaling NK T Cell Activation RRNA Base Methylation