EDN3 and EDNRB

Number of citations of the paper that reports this interaction (PMID 8001160)
102

Data Source:
HPRD (in vivo)

		EDN3	EDNRB
Gene Name		endothelin 3	endothelin receptor type B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane Membrane Raft
	Molecular Function	Receptor Binding Hormone Activity	Endothelin Receptor Activity Protein Binding Peptide Hormone Binding Type 1 Angiotensin Receptor Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Blood Circulation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Neutrophil Chemotaxis Vasoconstriction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Regulation Of Developmental Pigmentation Positive Regulation Of Potassium Ion Transmembrane Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of PH Cell Surface Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Peripheral Nervous System Development Posterior Midgut Development Aging Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Negative Regulation Of Neuron Maturation Response To Organic Cyclic Compound Vein Smooth Muscle Contraction Sensory Perception Of Pain CGMP-mediated Signaling Melanocyte Differentiation Regulation Of Fever Generation Negative Regulation Of Cellular Protein Metabolic Process Enteric Smooth Muscle Cell Differentiation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Epithelial Fluid Transport Vasoconstriction Vasodilation Negative Regulation Of Apoptotic Process Macrophage Chemotaxis Response To Pain Enteric Nervous System Development Regulation Of Epithelial Cell Proliferation Regulation Of Sensory Perception Of Pain Positive Regulation Of Penile Erection Cellular Response To Lipopolysaccharide Endothelin Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Bosentan Sitaxentan
Diseases
GWAS		Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 19430479 21909115) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)	Hair color ( 23548203) Total ventricular volume ( 21116278)
Protein-Protein Interactions		5 interactors: CMA1 CTSE EDNRA EDNRB KEL	7 interactors: CAV1 EDN1 EDN3 GNA11 GNA13 GRK6 NOS3
Entrez ID		1908	1910
HPRD ID		00570	08834
Ensembl ID		ENSG00000124205	ENSG00000136160
Uniprot IDs		P14138 Q4FAT2	P24530
PDB IDs
Enriched GO Terms of Interacting Partners?		Vasoconstriction Endothelin Receptor Signaling Pathway Blood Circulation Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Chemical Homeostasis Enteric Nervous System Development Vascular Smooth Muscle Contraction Cellular Homeostasis Regulation Of Blood Pressure Chemical Homeostasis Negative Regulation Of CAMP Biosynthetic Process Regulation Of Inflammatory Response Negative Regulation Of CAMP Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Nucleotide Metabolic Process Autonomic Nervous System Development Cellular Metal Ion Homeostasis Homeostatic Process Regulation Of Adenylate Cyclase Activity Cellular Cation Homeostasis Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Ion Homeostasis Regulation Of Cyclase Activity Metal Ion Homeostasis Neural Crest Cell Development Neural Crest Cell Differentiation Ion Homeostasis Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Renal System Process Regulation Of CAMP Metabolic Process Enteric Smooth Muscle Cell Differentiation Interleukin-1 Beta Biosynthetic Process Mesenchymal Cell Development Mesenchymal Cell Differentiation Posterior Midgut Development Nervous System Development Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cytosolic Calcium Ion Homeostasis Smooth Muscle Cell Proliferation Negative Regulation Of Neuron Maturation Mesenchyme Development Vein Smooth Muscle Contraction Fibroblast Proliferation Penile Erection Muscle Contraction	Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Contraction Vasoconstriction Regulation Of Body Fluid Levels Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Potassium Ion Transport Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Blood Circulation Regulation Of Oxidoreductase Activity Angiogenesis Regulation Of The Force Of Heart Contraction By Chemical Signal Cardiovascular System Development Regulation Of Systemic Arterial Blood Pressure Regulation Of Blood Coagulation Cellular Metal Ion Homeostasis Blood Coagulation Blood Vessel Morphogenesis Hemostasis Reactive Oxygen Species Metabolic Process Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Wound Healing Vascular Smooth Muscle Contraction Blood Vessel Development Second-messenger-mediated Signaling Cellular Chemical Homeostasis Vasculature Development Ion Homeostasis Inositol Phosphate-mediated Signaling Wound Healing Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Ion Transport Positive Regulation Of Heart Rate Negative Regulation Of Potassium Ion Transport Regulation Of Developmental Pigmentation Positive Regulation Of Ion Transport Positive Regulation Of Catalytic Activity Regulation Of Cellular Component Movement Cellular Homeostasis Response To Wounding Nitric Oxide Metabolic Process Signal Transduction Positive Regulation Of Heart Contraction
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1