CMA1 and EDN2

Number of citations of the paper that reports this interaction (PMID 9675146)
6

Data Source:
HPRD (in vitro)

		CMA1	EDN2
Gene Name		chymase 1, mast cell	endothelin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptide Binding	Hormone Activity
	Biological Process	Angiotensin Maturation Proteolysis Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Midbrain Development Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Interleukin-1 Beta Biosynthetic Process Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus	Prostaglandin Biosynthetic Process Temperature Homeostasis Positive Regulation Of Leukocyte Chemotaxis Hormonal Regulation Of The Force Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Regulation Of Vasoconstriction Calcium-mediated Signaling Neutrophil Chemotaxis Macrophage Activation Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Energy Homeostasis
Pathways		Signaling by SCF-KIT Peptide hormone metabolism Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Degradation of the extracellular matrix	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Phenylalanylmethane Benzylsulfinic Acid 2-(N-Morpholino)-Ethanesulfonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3	3 interactors: CMA1 KEL MME
Entrez ID		1215	1907
HPRD ID		00346	07173
Ensembl ID		ENSG00000092009	ENSG00000127129
Uniprot IDs		P23946 Q4FEB3	P20800
PDB IDs		1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69
Enriched GO Terms of Interacting Partners?		Vascular Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vasoconstriction Positive Regulation Of Oxidoreductase Activity Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Regulation Of Vasoconstriction Smooth Muscle Contraction Leukocyte Migration Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Oxidoreductase Activity Muscle System Process Inositol Phosphate-mediated Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Heart Contraction Second-messenger-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Cell Migration Regulation Of Cell Proliferation Regulation Of Catalytic Activity Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cell Motility Positive Regulation Of Immune System Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Protein Kinase Activity Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Kinase Activity Neutrophil Chemotaxis Neutrophil Migration Response To Mechanical Stimulus Positive Regulation Of MAP Kinase Activity Muscle Contraction Granulocyte Chemotaxis Positive Regulation Of Transferase Activity Regulation Of Nitric Oxide Biosynthetic Process Intracellular Signal Transduction Regulation Of Cell Migration	Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Blood Circulation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Peptide Hormone Processing Regulation Of Systemic Arterial Blood Pressure Peptide Metabolic Process Interleukin-1 Beta Biosynthetic Process Regulation Of Blood Pressure Hormone Metabolic Process Proteolysis Protein Processing Cellular Amide Metabolic Process Cellular Response To UV-A Regulation Of Hormone Levels Creatinine Metabolic Process Cellular Magnesium Ion Homeostasis Response To UV-A Regulation Of Axon Diameter Cellular Response To UV-B Regulation Of Cell Projection Size Cellular Chemical Homeostasis Interleukin-1 Beta Production Negative Regulation Of Potassium Ion Transmembrane Transport Magnesium Ion Homeostasis Response To UV-B Replicative Senescence Organ Development Beta-amyloid Metabolic Process Cellular Homeostasis Negative Regulation Of Potassium Ion Transport Skeletal Muscle Fiber Development Cytokine Biosynthetic Process Myotube Cell Development Cytokine Metabolic Process Chemical Homeostasis Vasoconstriction Regulation Of Potassium Ion Transmembrane Transport System Development Negative Regulation Of Ion Transmembrane Transport Muscle Fiber Development Negative Regulation Of Transmembrane Transport Myotube Differentiation Cellular Response To UV Regulation Of Potassium Ion Transport Cellular Response To Glucose Stimulus Multicellular Organismal Development Anatomical Structure Development Cell Aging
Tagcloud ?		a8 a9 aldehyde aldh3a1 beta4 biglycan chymase conjunctiva conjunctival fibrovascular gelsolin genechip immunofluorescent infiltrates itraq member1 pterygium rab10 s100 s100a8 s100a9 sawdust serpin serpina1 stringent thymosin uninvolved vim wing	albino ameliorates bright damaging dawley functioning glial gs inos lif light lux macroglial maintaining muller neuroprotective nm photoreceptors preconditioning pretreatment proper qpcr ranging red retina retinal s100beta sprague vimentin
Tagcloud (Difference) ?		a8 a9 aldehyde aldh3a1 beta4 biglycan chymase conjunctiva conjunctival fibrovascular gelsolin genechip immunofluorescent infiltrates itraq member1 pterygium rab10 s100 s100a8 s100a9 sawdust serpin serpina1 stringent thymosin uninvolved vim wing	albino ameliorates bright damaging dawley functioning glial gs inos lif light lux macroglial maintaining muller neuroprotective nm photoreceptors preconditioning pretreatment proper qpcr ranging red retina retinal s100beta sprague vimentin
Tagcloud (Intersection) ?