EDN3

Name	endothelin 3
Structure
Novel Interactors	1 novel interactors: LAMA5
Interactors	5 interactors: CMA1 CTSE EDNRA EDNRB KEL
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Hormone Activity Endothelin B Receptor Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Axon Guidance Blood Circulation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Gene Expression Intracellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Regulation Of Cell Migration Neutrophil Chemotaxis Neuron Projection Development Vasoconstriction Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Hormone Secretion Regulation Of Developmental Pigmentation Axon Extension Establishment Of Localization In Cell Potassium Ion Transmembrane Transport Blood Vessel Diameter Maintenance Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways	Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Diseases	Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD) Waardenburg syndrome (WS)
GWAS	Blood pressure ( 21909110 ) Diastolic blood pressure ( 21909115 27618452 28739976 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Hypertension ( 19430479 21909115 ) Metabolite levels ( 23823483 ) Response to diuretic therapy in hypertension ( 23753411 ) Systolic blood pressure ( 21909115 27618447 27618452 28739976 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 )
Entrez ID	1908
HPRD ID	00570
Ensembl ID	ENSG00000124205
Uniprot IDs	P14138 Q4FAT2
PDB IDs	6IGK
GO Terms Enriched among Interactors ?	Vasoconstriction Endothelin Receptor Activity Renal Albumin Absorption Neural Crest Cell Migration Mesenchymal Cell Migration Renal Protein Absorption Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Developmental Pigmentation Ameboidal-type Cell Migration Blood Vessel Diameter Maintenance Regulation Of Tube Size Vascular Associated Smooth Muscle Contraction Renal Sodium Ion Absorption Renal Sodium Ion Transport Cell Differentiation Involved In Kidney Development Sodium Ion Homeostasis Establishment Of Endothelial Barrier Vascular Process In Circulatory System Chemical Homeostasis Endothelial Cell Development Renal Absorption Pigmentation Circulatory System Process Smooth Muscle Contraction Inorganic Ion Homeostasis Protein Transmembrane Transport Peptidase Activity Enteric Smooth Muscle Cell Differentiation Proteoglycan Metabolic Process Monoatomic Cation Homeostasis Homeostatic Process Monoatomic Ion Homeostasis Muscle Cell Development Canonical Wnt Signaling Pathway Regulation Of Heart Rate Intracellular Chemical Homeostasis Renal System Process Podocyte Apoptotic Process Cellular Response To Human Chorionic Gonadotropin Stimulus Posterior Midgut Development Extracellular Matrix Of Synaptic Cleft Protein Metabolic Process Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metal Ion Transport Cellular Homeostasis Basement Membrane Disassembly Semaphorin-plexin Signaling Pathway Involved In Axon Guidance