CMA1 and KITLG

Number of citations of the paper that reports this interaction (PMID 10224464)
0

Data Source:
HPRD (in vitro)

		CMA1	KITLG
Gene Name		chymase 1, mast cell	KIT ligand
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Extracellular Matrix	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptide Binding	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Angiotensin Maturation Proteolysis Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Midbrain Development Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Interleukin-1 Beta Biosynthetic Process Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus	Neural Crest Cell Migration Positive Regulation Of Myeloid Leukocyte Differentiation Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Melanocyte Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by SCF-KIT Peptide hormone metabolism Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Degradation of the extracellular matrix
Drugs		Phenylalanylmethane Benzylsulfinic Acid 2-(N-Morpholino)-Ethanesulfonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID
Diseases
GWAS			Blond vs. brown hair color ( 17952075) Hair color ( 23548203) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 23666239 23666240)
Protein-Protein Interactions		10 interactors: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3	8 interactors: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD UBE2V1
Entrez ID		1215	4254
HPRD ID		00346	01698
Ensembl ID		ENSG00000092009
Uniprot IDs		P23946 Q4FEB3	P21583
PDB IDs		1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69	1EXZ 1SCF 2E9W
Enriched GO Terms of Interacting Partners?		Vascular Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vasoconstriction Positive Regulation Of Oxidoreductase Activity Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Regulation Of Vasoconstriction Smooth Muscle Contraction Leukocyte Migration Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Oxidoreductase Activity Muscle System Process Inositol Phosphate-mediated Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Heart Contraction Second-messenger-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Cell Migration Regulation Of Cell Proliferation Regulation Of Catalytic Activity Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cell Motility Positive Regulation Of Immune System Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Protein Kinase Activity Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Kinase Activity Neutrophil Chemotaxis Neutrophil Migration Response To Mechanical Stimulus Positive Regulation Of MAP Kinase Activity Muscle Contraction Granulocyte Chemotaxis Positive Regulation Of Transferase Activity Regulation Of Nitric Oxide Biosynthetic Process Intracellular Signal Transduction Regulation Of Cell Migration	Erythropoietin-mediated Signaling Pathway Mast Cell Differentiation Cellular Response To Erythropoietin Mast Cell Chemotaxis Leukocyte Differentiation Myeloid Leukocyte Differentiation Cytokine Production Leukocyte Activation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Hemopoiesis Mast Cell Degranulation Cell Activation Mast Cell Mediated Immunity Fc-epsilon Receptor Signaling Pathway Immune System Development Embryonic Hemopoiesis Lysosome Localization Lymphocyte Differentiation Mast Cell Activation Myeloid Cell Differentiation Fc Receptor Signaling Pathway Leukocyte Degranulation Positive Regulation Of Cell Proliferation Organ Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulated Secretory Pathway Cellular Response To Organic Substance Positive Regulation Of JAK-STAT Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Developmental Process Lymphocyte Activation Immune System Process Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Error-free Postreplication DNA Repair Mast Cell Proliferation Interleukin-1 Beta Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of JAK-STAT Cascade Embryonic Organ Development Reproductive Structure Development Reproductive System Development Immune Response Regulation Of Immune System Process Leukocyte Chemotaxis Response To Organic Substance T Cell Receptor Signaling Pathway System Development Kit Signaling Pathway
Tagcloud ?		a8 a9 aldehyde aldh3a1 beta4 biglycan chymase conjunctiva conjunctival fibrovascular gelsolin genechip immunofluorescent infiltrates itraq member1 pterygium rab10 s100 s100a8 s100a9 sawdust serpin serpina1 stringent thymosin uninvolved vim wing	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		a8 a9 aldehyde aldh3a1 beta4 biglycan chymase conjunctiva conjunctival fibrovascular gelsolin genechip immunofluorescent infiltrates itraq member1 pterygium rab10 s100 s100a8 s100a9 sawdust serpin serpina1 stringent thymosin uninvolved vim wing	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?