CMA1 and MMP1

Number of citations of the paper that reports this interaction (PMID 8027075)
36

Data Source:
HPRD (in vitro, in vivo)

		CMA1	MMP1
Gene Name		chymase 1, mast cell	matrix metallopeptidase 1 (interstitial collagenase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptide Binding	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Angiotensin Maturation Proteolysis Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Midbrain Development Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Interleukin-1 Beta Biosynthetic Process Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus	Proteolysis Blood Coagulation Viral Process Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein Oligomerization Cellular Protein Metabolic Process Leukocyte Migration
Pathways		Signaling by SCF-KIT Peptide hormone metabolism Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Degradation of the extracellular matrix	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Basigin interactions Cell surface interactions at the vascular wall
Drugs		Phenylalanylmethane Benzylsulfinic Acid 2-(N-Morpholino)-Ethanesulfonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID	Marimastat N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-[3-(N\'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3	17 interactors: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11
Entrez ID		1215	4312
HPRD ID		00346	00384
Ensembl ID		ENSG00000092009	ENSG00000196611
Uniprot IDs		P23946 Q4FEB3	B4DN15 P03956 Q53G95
PDB IDs		1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69	1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C
Enriched GO Terms of Interacting Partners?		Vascular Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vasoconstriction Positive Regulation Of Oxidoreductase Activity Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Regulation Of Vasoconstriction Smooth Muscle Contraction Leukocyte Migration Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Oxidoreductase Activity Muscle System Process Inositol Phosphate-mediated Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Heart Contraction Second-messenger-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Cell Migration Regulation Of Cell Proliferation Regulation Of Catalytic Activity Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cell Motility Positive Regulation Of Immune System Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Protein Kinase Activity Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Kinase Activity Neutrophil Chemotaxis Neutrophil Migration Response To Mechanical Stimulus Positive Regulation Of MAP Kinase Activity Muscle Contraction Granulocyte Chemotaxis Positive Regulation Of Transferase Activity Regulation Of Nitric Oxide Biosynthetic Process Intracellular Signal Transduction Regulation Of Cell Migration	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Migration Cell Migration Locomotion Cell Motility Monocyte Chemotaxis Organ Morphogenesis Movement Of Cell Or Subcellular Component Leukocyte Chemotaxis Chemotaxis Response To Stress Cell Chemotaxis Regulation Of Protein Metabolic Process Response To Wounding Organ Development Glycosaminoglycan Catabolic Process Blood Coagulation Inflammatory Response Hemostasis Granulocyte Chemotaxis Eosinophil Chemotaxis Response To Organic Substance Eosinophil Migration Connective Tissue Development Homeostatic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Positive Regulation Of Leukocyte Migration Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Developmental Process Ossification Regulation Of Cell Migration Wound Healing Proteoglycan Metabolic Process Calcium Ion Homeostasis Regulation Of Cell Motility Positive Regulation Of Chemotaxis Response To Stimulus Regulation Of Leukocyte Migration Regulation Of Locomotion Negative Regulation Of Proteolysis Regulation Of Cellular Component Movement Positive Regulation Of Behavior Regulation Of Catalytic Activity Tissue Development Negative Regulation Of Protein Processing Anatomical Structure Morphogenesis
Tagcloud ?		a8 a9 aldehyde aldh3a1 beta4 biglycan chymase conjunctiva conjunctival fibrovascular gelsolin genechip immunofluorescent infiltrates itraq member1 pterygium rab10 s100 s100a8 s100a9 sawdust serpin serpina1 stringent thymosin uninvolved vim wing	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Difference) ?		a8 a9 aldehyde aldh3a1 beta4 biglycan chymase conjunctiva conjunctival fibrovascular gelsolin genechip immunofluorescent infiltrates itraq member1 pterygium rab10 s100 s100a8 s100a9 sawdust serpin serpina1 stringent thymosin uninvolved vim wing	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Intersection) ?