CMA1

Gene Name		chymase 1, mast cell
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptide Binding
	Biological Process	Angiotensin Maturation Proteolysis Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Midbrain Development Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Interleukin-1 Beta Biosynthetic Process Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus
Pathways		Signaling by SCF-KIT Peptide hormone metabolism Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Degradation of the extracellular matrix
Drugs		Phenylalanylmethane Benzylsulfinic Acid 2-(N-Morpholino)-Ethanesulfonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID
Diseases
GWAS
Protein-protein Interactions		10 interactors: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3
Entrez ID		1215
HPRD ID		00346
Ensembl ID		ENSG00000092009
Uniprot IDs		P23946 Q4FEB3
PDB IDs		1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69
Enriched GO Terms of Interacting Partners?		Vascular Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vasoconstriction Positive Regulation Of Oxidoreductase Activity Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Regulation Of Vasoconstriction Smooth Muscle Contraction Leukocyte Migration Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Oxidoreductase Activity Muscle System Process Inositol Phosphate-mediated Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Heart Contraction Second-messenger-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Cell Migration Regulation Of Cell Proliferation Regulation Of Catalytic Activity Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cell Motility Positive Regulation Of Immune System Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Protein Kinase Activity Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Kinase Activity Neutrophil Chemotaxis Neutrophil Migration Response To Mechanical Stimulus Positive Regulation Of MAP Kinase Activity Muscle Contraction Granulocyte Chemotaxis Positive Regulation Of Transferase Activity Regulation Of Nitric Oxide Biosynthetic Process Intracellular Signal Transduction Regulation Of Cell Migration
Tagcloud ?		a8 a9 aldehyde aldh3a1 beta4 biglycan chymase conjunctiva conjunctival fibrovascular gelsolin genechip immunofluorescent infiltrates itraq member1 pterygium rab10 s100 s100a8 s100a9 sawdust serpin serpina1 stringent thymosin uninvolved vim wing