EDN3 and KEL

Number of citations of the paper that reports this interaction (PMID 10438732)
14

Data Source:
HPRD (in vivo)

		EDN3	KEL
Gene Name		endothelin 3	Kell blood group, metallo-endopeptidase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Hormone Activity	Metalloendopeptidase Activity Protein Binding Metal Ion Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Blood Circulation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Neutrophil Chemotaxis Vasoconstriction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Regulation Of Developmental Pigmentation Positive Regulation Of Potassium Ion Transmembrane Transport	Proteolysis Cellular Calcium Ion Homeostasis Regulation Of Cell Size Cellular Magnesium Ion Homeostasis Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Negative Regulation Of Potassium Ion Transmembrane Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 19430479 21909115) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		5 interactors: CMA1 CTSE EDNRA EDNRB KEL	7 interactors: EDN1 EDN2 EDN3 EWSR1 TUBA1A UBC XK
Entrez ID		1908	3792
HPRD ID		00570	00194
Ensembl ID		ENSG00000124205	ENSG00000197993
Uniprot IDs		P14138 Q4FAT2	P23276
PDB IDs
Enriched GO Terms of Interacting Partners?		Vasoconstriction Endothelin Receptor Signaling Pathway Blood Circulation Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Chemical Homeostasis Enteric Nervous System Development Vascular Smooth Muscle Contraction Cellular Homeostasis Regulation Of Blood Pressure Chemical Homeostasis Negative Regulation Of CAMP Biosynthetic Process Regulation Of Inflammatory Response Negative Regulation Of CAMP Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Nucleotide Metabolic Process Autonomic Nervous System Development Cellular Metal Ion Homeostasis Homeostatic Process Regulation Of Adenylate Cyclase Activity Cellular Cation Homeostasis Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Ion Homeostasis Regulation Of Cyclase Activity Metal Ion Homeostasis Neural Crest Cell Development Neural Crest Cell Differentiation Ion Homeostasis Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Renal System Process Regulation Of CAMP Metabolic Process Enteric Smooth Muscle Cell Differentiation Interleukin-1 Beta Biosynthetic Process Mesenchymal Cell Development Mesenchymal Cell Differentiation Posterior Midgut Development Nervous System Development Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cytosolic Calcium Ion Homeostasis Smooth Muscle Cell Proliferation Negative Regulation Of Neuron Maturation Mesenchyme Development Vein Smooth Muscle Contraction Fibroblast Proliferation Penile Erection Muscle Contraction	Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vascular Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Positive Regulation Of Heart Rate Positive Regulation Of Heart Contraction Vasoconstriction Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Regulation Of Vasoconstriction Smooth Muscle Contraction Positive Regulation Of Leukocyte Chemotaxis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Rate Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Positive Regulation Of Leukocyte Migration Tonic Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure Cellular Metal Ion Homeostasis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of Behavior Metal Ion Homeostasis Regulation Of Chemotaxis Second-messenger-mediated Signaling Cellular Chemical Homeostasis Magnesium Ion Homeostasis Ion Homeostasis Regulation Of Heart Contraction Cellular Response To Cytokine Stimulus Regulation Of Blood Pressure Regulation Of Behavior Prostaglandin Biosynthetic Process Cellular Homeostasis Positive Regulation Of MAP Kinase Activity Response To Cytokine Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Cell Cycle Process Prostaglandin Metabolic Process Muscle System Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Oxidoreductase Activity Chemical Homeostasis Positive Regulation Of Cell Cycle
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	abortions anomaly behave comes couples desert disequilibrium distortion epistatically fertility grc haplotypes histocompatibility hla homozygosity homozygotes immunogenetic inbreeding kummer linkage nomads reacts reproduction rt1 segregation specificities sterility tuaregs unusually
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	abortions anomaly behave comes couples desert disequilibrium distortion epistatically fertility grc haplotypes histocompatibility hla homozygosity homozygotes immunogenetic inbreeding kummer linkage nomads reacts reproduction rt1 segregation specificities sterility tuaregs unusually
Tagcloud (Intersection) ?