EDN3 and KEL

Number of citations: 0 (PubMedID 10438732)
Data Source: HPRD (in vivo)

		EDN3	KEL
Name		endothelin 3	Kell metallo-endopeptidase (Kell blood group)
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Endothelin B Receptor Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Axon Guidance Blood Circulation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Gene Expression Intracellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Regulation Of Cell Migration Neutrophil Chemotaxis Neuron Projection Development Vasoconstriction Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Hormone Secretion Regulation Of Developmental Pigmentation Axon Extension Establishment Of Localization In Cell Potassium Ion Transmembrane Transport Blood Vessel Diameter Maintenance Positive Regulation Of Potassium Ion Transmembrane Transport	Proteolysis Intracellular Calcium Ion Homeostasis Regulation Of Cell Size Intracellular Magnesium Ion Homeostasis Protein Processing Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Establishment Of Localization In Cell Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	Peptide ligand-binding receptors
Drugs		None	Phosphoramidon
Diseases		Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD) Waardenburg syndrome (WS)	None
GWAS		Blood pressure ( 21909110 ) Diastolic blood pressure ( 21909115 27618452 28739976 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Hypertension ( 19430479 21909115 ) Metabolite levels ( 23823483 ) Response to diuretic therapy in hypertension ( 23753411 ) Systolic blood pressure ( 21909115 27618447 27618452 28739976 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 )	Alcoholic chronic pancreatitis ( 28754779 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 )
Interacting Genes		5 interacting genes: CMA1 CTSE EDNRA EDNRB KEL	12 interacting genes: ADIPOQ C3orf52 C5 CLDN19 EDN1 EDN2 EDN3 EWSR1 PM20D2 TUBA1A UBC XK
Entrez ID		1908	3792
HPRD ID		00570	00194
Ensembl ID		ENSG00000124205	ENSG00000197993
Uniprot IDs		P14138 Q4FAT2	A0A077QP03 P23276
PDB IDs		6IGK	Not available
GO Terms Enriched among Interactors		Vasoconstriction Endothelin Receptor Activity Renal Albumin Absorption Neural Crest Cell Migration Mesenchymal Cell Migration Renal Protein Absorption Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Developmental Pigmentation Ameboidal-type Cell Migration Blood Vessel Diameter Maintenance Regulation Of Tube Size Vascular Associated Smooth Muscle Contraction Renal Sodium Ion Absorption Renal Sodium Ion Transport Cell Differentiation Involved In Kidney Development Sodium Ion Homeostasis Establishment Of Endothelial Barrier Vascular Process In Circulatory System Chemical Homeostasis Endothelial Cell Development Renal Absorption Pigmentation Circulatory System Process Smooth Muscle Contraction Inorganic Ion Homeostasis Protein Transmembrane Transport Peptidase Activity Enteric Smooth Muscle Cell Differentiation Proteoglycan Metabolic Process Monoatomic Cation Homeostasis Homeostatic Process Monoatomic Ion Homeostasis Muscle Cell Development Canonical Wnt Signaling Pathway Regulation Of Heart Rate Intracellular Chemical Homeostasis Renal System Process Podocyte Apoptotic Process Cellular Response To Human Chorionic Gonadotropin Stimulus Posterior Midgut Development Extracellular Matrix Of Synaptic Cleft Protein Metabolic Process Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metal Ion Transport Cellular Homeostasis Basement Membrane Disassembly Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Endothelin B Receptor Binding Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Positive Regulation Of Heart Rate Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Hormone Activity Positive Regulation Of Smooth Muscle Contraction Vasoconstriction Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Heart Contraction Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure Axon Extension Regulation Of Blood Pressure Positive Regulation Of Muscle Contraction Intracellular Magnesium Ion Homeostasis Neutrophil Chemotaxis Smooth Muscle Contraction Intracellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Cell Chemotaxis Regulation Of Chemotaxis Regulation Of Vasoconstriction Neutrophil Migration Positive Regulation Of Prostaglandin Biosynthetic Process Calcium Ion Homeostasis Regulation Of Leukocyte Migration Leukocyte Migration Granulocyte Chemotaxis Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Neuron Projection Extension Endothelin Receptor Signaling Pathway Regulation Of Prostaglandin Biosynthetic Process Magnesium Ion Homeostasis Granulocyte Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Fatty Acid Metabolic Process Regulation Of Cell Migration Regulation Of Heart Rate Regulation Of Cell Motility Regulation Of Locomotion Chemotaxis Developmental Cell Growth Response To Tumor Necrosis Factor Regulation Of Ketone Metabolic Process Myeloid Leukocyte Migration Locomotion