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EDN3 and EDNRA
Number of citations of the paper that reports this interaction (PubMedID
11982704
)
0
Data Source:
HPRD
(in vivo, in vitro)
EDN3
EDNRA
Description
endothelin 3
endothelin receptor type A
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Membrane
Molecular Function
Signaling Receptor Binding
Hormone Activity
Endothelin B Receptor Binding
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
G Protein-coupled Receptor Activity
Endothelin Receptor Activity
Protein Binding
Biological Process
Neural Crest Cell Migration
Positive Regulation Of Leukocyte Chemotaxis
Regulation Of Systemic Arterial Blood Pressure By Endothelin
Intracellular Calcium Ion Homeostasis
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell-cell Signaling
Axon Guidance
Blood Circulation
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Heart Rate
Regulation Of Gene Expression
Intracellular Magnesium Ion Homeostasis
Artery Smooth Muscle Contraction
Vein Smooth Muscle Contraction
Regulation Of Vasoconstriction
Peptide Hormone Secretion
Neuron Differentiation
Melanocyte Differentiation
Regulation Of Cell Migration
Neutrophil Chemotaxis
Neuron Projection Development
Vasoconstriction
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Differentiation
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Smooth Muscle Contraction
Positive Regulation Of Hormone Secretion
Regulation Of Developmental Pigmentation
Axon Extension
Establishment Of Localization In Cell
Potassium Ion Transmembrane Transport
Blood Vessel Diameter Maintenance
Positive Regulation Of Potassium Ion Transmembrane Transport
Mitotic Cell Cycle
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
Response To Hypoxia
In Utero Embryonic Development
Blood Vessel Remodeling
Response To Amphetamine
Regulation Of Heart Rate
Heart Process
Glomerular Filtration
Cardiac Chamber Formation
Left Ventricular Cardiac Muscle Tissue Morphogenesis
Atrial Cardiac Muscle Tissue Development
Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Noradrenergic Neuron Differentiation
Intracellular Calcium Ion Homeostasis
Smooth Muscle Contraction
Mitochondrion Organization
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Axon Guidance
Heart Development
Respiratory Gaseous Exchange By Respiratory System
Regulation Of Blood Pressure
Cell Population Proliferation
Response To Wounding
Gene Expression
Regulation Of D-glucose Transmembrane Transport
Neural Crest Cell Development
Neural Crest Cell Differentiation
Neural Crest Cell Fate Commitment
Artery Smooth Muscle Contraction
Vascular Associated Smooth Muscle Contraction
Neuron Remodeling
Heparin Proteoglycan Metabolic Process
Thyroid Gland Development
Neuron Projection Development
Glomerulus Development
Cellular Response To Oxidative Stress
Embryonic Heart Tube Development
Aorta Development
Vasoconstriction
Norepinephrine Metabolic Process
Middle Ear Morphogenesis
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cellular Response To Human Chorionic Gonadotropin Stimulus
Developmental Pigmentation
Enteric Nervous System Development
Sympathetic Nervous System Development
Axon Extension
Embryonic Skeletal System Development
Neuromuscular Process
Sodium Ion Homeostasis
Canonical Wnt Signaling Pathway
Head Development
Face Development
Axonogenesis Involved In Innervation
Establishment Of Endothelial Barrier
Pharyngeal Arch Artery Morphogenesis
Renal Sodium Ion Absorption
Calcium Ion Transmembrane Transport
Cellular Response To Follicle-stimulating Hormone Stimulus
Cellular Response To Luteinizing Hormone Stimulus
Protein Transmembrane Transport
Glomerular Endothelium Development
Podocyte Differentiation
Endothelin Receptor Signaling Pathway
Endothelin Receptor Signaling Pathway Involved In Heart Process
Renal Albumin Absorption
Vascular Associated Smooth Muscle Cell Development
Mesenchymal Cell Apoptotic Process
Cellular Response To Toxic Substance
Sympathetic Neuron Axon Guidance
CAMP/PKA Signal Transduction
Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Podocyte Apoptotic Process
Meiotic Cell Cycle Process Involved In Oocyte Maturation
Cranial Skeletal System Development
Response To Acetylcholine
Regulation Of Protein Localization To Cell Leading Edge
Positive Regulation Of Cation Channel Activity
Pathways
Peptide ligand-binding receptors
G alpha (q) signalling events
Transcriptional and post-translational regulation of MITF-M expression and activity
Peptide ligand-binding receptors
G alpha (q) signalling events
Drugs
Bosentan
Acetylsalicylic acid
2-HYDROXY-3,5-DIIODOBENZOIC ACID
Darusentan
SPP 301
Actelion-1
Atrasentan
Sitaxentan
Ambrisentan
Enrasentan
Tezosentan
Clazosentan
Macitentan
Sparsentan
Diseases
Congenital central hypoventilation syndrome (CCHS)
Hirschsprung disease (HD)
Waardenburg syndrome (WS)
GWAS
Blood pressure (
21909110
)
Diastolic blood pressure (
21909115
27618452
28739976
)
Diastolic blood pressure (cigarette smoking interaction) (
29455858
)
Hypertension (
19430479
21909115
)
Metabolite levels (
23823483
)
Response to diuretic therapy in hypertension (
23753411
)
Systolic blood pressure (
21909115
27618447
27618452
28739976
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Carotid intima media thickness (
21909108
)
Carotid plaque (
30510157
)
Coronary artery disease (
33020668
24262325
32469254
26343387
29212778
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Coronary artery disease or large artery stroke (
24262325
)
Dental caries (
23064961
)
Intracranial aneurysm (
22286173
)
Lead levels (
26025379
)
Myocardial infarction (
33532862
26343387
)
Obesity-related traits (
23251661
)
Pancreatic cancer (
29422604
)
Pancreatic ductal adenocarcinoma (
30541042
)
Peripheral artery disease (
26488411
31285632
)
Plasma clusterin levels (
26545630
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Pulse pressure (
27841878
)
Red blood cell count (
32888494
)
Resting heart rate (
27798624
)
Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome (
30621171
)
Smoking initiation (
33082346
)
Systolic blood pressure (
27841878
)
Interacting Genes
5 interacting genes:
CMA1
CTSE
EDNRA
EDNRB
KEL
7 interacting genes:
EDN1
EDN3
GNA11
GNAI2
GRK6
HDAC7
KAT5
Entrez ID
1908
1909
HPRD ID
00570
00571
Ensembl ID
ENSG00000124205
ENSG00000151617
Uniprot IDs
P14138
Q4FAT2
P25101
PDB IDs
6IGK
8HCQ
8XVI
8XVJ
8XVK
8XVL
Enriched GO Terms of Interacting Partners
?
Vasoconstriction
Endothelin Receptor Activity
Renal Albumin Absorption
Neural Crest Cell Migration
Mesenchymal Cell Migration
Renal Protein Absorption
Heparin Proteoglycan Metabolic Process
Enteric Nervous System Development
Endothelin Receptor Signaling Pathway
Podocyte Differentiation
Developmental Pigmentation
Ameboidal-type Cell Migration
Blood Vessel Diameter Maintenance
Regulation Of Tube Size
Vascular Associated Smooth Muscle Contraction
Renal Sodium Ion Absorption
Renal Sodium Ion Transport
Cell Differentiation Involved In Kidney Development
Sodium Ion Homeostasis
Establishment Of Endothelial Barrier
Vascular Process In Circulatory System
Chemical Homeostasis
Endothelial Cell Development
Renal Absorption
Pigmentation
Circulatory System Process
Smooth Muscle Contraction
Inorganic Ion Homeostasis
Protein Transmembrane Transport
Peptidase Activity
Enteric Smooth Muscle Cell Differentiation
Proteoglycan Metabolic Process
Monoatomic Cation Homeostasis
Homeostatic Process
Monoatomic Ion Homeostasis
Muscle Cell Development
Canonical Wnt Signaling Pathway
Regulation Of Heart Rate
Intracellular Chemical Homeostasis
Renal System Process
Podocyte Apoptotic Process
Cellular Response To Human Chorionic Gonadotropin Stimulus
Posterior Midgut Development
Extracellular Matrix Of Synaptic Cleft
Protein Metabolic Process
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Metal Ion Transport
Cellular Homeostasis
Basement Membrane Disassembly
Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Vein Smooth Muscle Contraction
Endothelin B Receptor Binding
Regulation Of Systemic Arterial Blood Pressure By Endothelin
Artery Smooth Muscle Contraction
Tonic Smooth Muscle Contraction
Positive Regulation Of Urine Volume
Endothelin Receptor Signaling Pathway
Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Hormone Secretion
Vascular Associated Smooth Muscle Contraction
Guanyl Nucleotide Binding
Regulation Of Urine Volume
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Blood Pressure
Regulation Of Secretion By Cell
G Protein-coupled Acetylcholine Receptor Signaling Pathway
G-protein Beta/gamma-subunit Complex Binding
Negative Regulation Of Interleukin-2 Production
Positive Regulation Of Heart Rate
Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal
Regulation Of Secretion
Positive Regulation Of Smooth Muscle Contraction
Vasoconstriction
Heterotrimeric G-protein Complex
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Heart Contraction
Regulation Of Cell Differentiation
Regulation Of Hormone Secretion
Positive Regulation Of Cell Cycle Process
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Acetylcholine Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Regulation Of Systemic Arterial Blood Pressure
Positive Regulation Of Mitotic Nuclear Division
Axon Extension
Positive Regulation Of Secretion By Cell
Positive Regulation Of Muscle Contraction
Postsynaptic Signal Transduction
Neural Crest Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Secretion
Mesenchymal Cell Migration
Smooth Muscle Contraction
Positive Regulation Of Cell Cycle
Regulation Of Smooth Muscle Contraction
Regulation Of Interleukin-2 Production
Regulation Of Vasoconstriction
Neutrophil Migration
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Tagcloud (Intersection)
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