EDN3 and EDNRA

Number of citations: 0 (PubMedID 11982704)
Data Source: HPRD (in vivo, in vitro)

		EDN3	EDNRA
Name		endothelin 3	endothelin receptor type A
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Endothelin B Receptor Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Endothelin Receptor Activity Protein Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Axon Guidance Blood Circulation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Gene Expression Intracellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Regulation Of Cell Migration Neutrophil Chemotaxis Neuron Projection Development Vasoconstriction Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Hormone Secretion Regulation Of Developmental Pigmentation Axon Extension Establishment Of Localization In Cell Potassium Ion Transmembrane Transport Blood Vessel Diameter Maintenance Positive Regulation Of Potassium Ion Transmembrane Transport	Mitotic Cell Cycle Angiogenesis Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Blood Vessel Remodeling Response To Amphetamine Regulation Of Heart Rate Heart Process Glomerular Filtration Cardiac Chamber Formation Left Ventricular Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Tissue Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Noradrenergic Neuron Differentiation Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Mitochondrion Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Heart Development Respiratory Gaseous Exchange By Respiratory System Regulation Of Blood Pressure Cell Population Proliferation Response To Wounding Gene Expression Regulation Of D-glucose Transmembrane Transport Neural Crest Cell Development Neural Crest Cell Differentiation Neural Crest Cell Fate Commitment Artery Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Neuron Remodeling Heparin Proteoglycan Metabolic Process Thyroid Gland Development Neuron Projection Development Glomerulus Development Cellular Response To Oxidative Stress Embryonic Heart Tube Development Aorta Development Vasoconstriction Norepinephrine Metabolic Process Middle Ear Morphogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Human Chorionic Gonadotropin Stimulus Developmental Pigmentation Enteric Nervous System Development Sympathetic Nervous System Development Axon Extension Embryonic Skeletal System Development Neuromuscular Process Sodium Ion Homeostasis Canonical Wnt Signaling Pathway Head Development Face Development Axonogenesis Involved In Innervation Establishment Of Endothelial Barrier Pharyngeal Arch Artery Morphogenesis Renal Sodium Ion Absorption Calcium Ion Transmembrane Transport Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Luteinizing Hormone Stimulus Protein Transmembrane Transport Glomerular Endothelium Development Podocyte Differentiation Endothelin Receptor Signaling Pathway Endothelin Receptor Signaling Pathway Involved In Heart Process Renal Albumin Absorption Vascular Associated Smooth Muscle Cell Development Mesenchymal Cell Apoptotic Process Cellular Response To Toxic Substance Sympathetic Neuron Axon Guidance CAMP/PKA Signal Transduction Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Podocyte Apoptotic Process Meiotic Cell Cycle Process Involved In Oocyte Maturation Cranial Skeletal System Development Response To Acetylcholine Regulation Of Protein Localization To Cell Leading Edge Positive Regulation Of Cation Channel Activity
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		None	Bosentan Acetylsalicylic acid 2-HYDROXY-3,5-DIIODOBENZOIC ACID Darusentan SPP 301 Actelion-1 Atrasentan Sitaxentan Ambrisentan Enrasentan Tezosentan Clazosentan Macitentan Sparsentan
Diseases		Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD) Waardenburg syndrome (WS)	None
GWAS		Blood pressure ( 21909110 ) Diastolic blood pressure ( 21909115 27618452 28739976 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Hypertension ( 19430479 21909115 ) Metabolite levels ( 23823483 ) Response to diuretic therapy in hypertension ( 23753411 ) Systolic blood pressure ( 21909115 27618447 27618452 28739976 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 )	Carotid intima media thickness ( 21909108 ) Carotid plaque ( 30510157 ) Coronary artery disease ( 33020668 24262325 32469254 26343387 29212778 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary artery disease or large artery stroke ( 24262325 ) Dental caries ( 23064961 ) Intracranial aneurysm ( 22286173 ) Lead levels ( 26025379 ) Myocardial infarction ( 33532862 26343387 ) Obesity-related traits ( 23251661 ) Pancreatic cancer ( 29422604 ) Pancreatic ductal adenocarcinoma ( 30541042 ) Peripheral artery disease ( 26488411 31285632 ) Plasma clusterin levels ( 26545630 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Pulse pressure ( 27841878 ) Red blood cell count ( 32888494 ) Resting heart rate ( 27798624 ) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171 ) Smoking initiation ( 33082346 ) Systolic blood pressure ( 27841878 )
Interacting Genes		5 interacting genes: CMA1 CTSE EDNRA EDNRB KEL	7 interacting genes: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5
Entrez ID		1908	1909
HPRD ID		00570	00571
Ensembl ID		ENSG00000124205	ENSG00000151617
Uniprot IDs		P14138 Q4FAT2	P25101
PDB IDs		6IGK	8HCQ 8XVI 8XVJ 8XVK 8XVL
GO Terms Enriched among Interactors		Vasoconstriction Endothelin Receptor Activity Renal Albumin Absorption Neural Crest Cell Migration Mesenchymal Cell Migration Renal Protein Absorption Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Developmental Pigmentation Ameboidal-type Cell Migration Blood Vessel Diameter Maintenance Regulation Of Tube Size Vascular Associated Smooth Muscle Contraction Renal Sodium Ion Absorption Renal Sodium Ion Transport Cell Differentiation Involved In Kidney Development Sodium Ion Homeostasis Establishment Of Endothelial Barrier Vascular Process In Circulatory System Chemical Homeostasis Endothelial Cell Development Renal Absorption Pigmentation Circulatory System Process Smooth Muscle Contraction Inorganic Ion Homeostasis Protein Transmembrane Transport Peptidase Activity Enteric Smooth Muscle Cell Differentiation Proteoglycan Metabolic Process Monoatomic Cation Homeostasis Homeostatic Process Monoatomic Ion Homeostasis Muscle Cell Development Canonical Wnt Signaling Pathway Regulation Of Heart Rate Intracellular Chemical Homeostasis Renal System Process Podocyte Apoptotic Process Cellular Response To Human Chorionic Gonadotropin Stimulus Posterior Midgut Development Extracellular Matrix Of Synaptic Cleft Protein Metabolic Process Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metal Ion Transport Cellular Homeostasis Basement Membrane Disassembly Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Vein Smooth Muscle Contraction Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure By Endothelin Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Positive Regulation Of Urine Volume Endothelin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Vascular Associated Smooth Muscle Contraction Guanyl Nucleotide Binding Regulation Of Urine Volume Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Blood Pressure Regulation Of Secretion By Cell G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Interleukin-2 Production Positive Regulation Of Heart Rate Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Secretion Positive Regulation Of Smooth Muscle Contraction Vasoconstriction Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Contraction Regulation Of Cell Differentiation Regulation Of Hormone Secretion Positive Regulation Of Cell Cycle Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mitotic Nuclear Division Axon Extension Positive Regulation Of Secretion By Cell Positive Regulation Of Muscle Contraction Postsynaptic Signal Transduction Neural Crest Cell Migration Neutrophil Chemotaxis Positive Regulation Of Secretion Mesenchymal Cell Migration Smooth Muscle Contraction Positive Regulation Of Cell Cycle Regulation Of Smooth Muscle Contraction Regulation Of Interleukin-2 Production Regulation Of Vasoconstriction Neutrophil Migration