IKBIP and TPM3

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		IKBIP	TPM3
Description		IKBKB interacting protein	tropomyosin 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Stress Fiber Cytoplasm Mitochondrion Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Response To X-ray	Muscle Contraction Actin Filament Organization
Pathways		Regulation of NF-kappa B signaling	Striated Muscle Contraction Smooth Muscle Contraction RHOV GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs			Phenethyl Isothiocyanate
Diseases			Congenital fiber type disproportion (CFTD) Cap myopathy Thyroid cancer Nemaline myopathy
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		17 interacting genes: APP BBLN CMTM3 GPR25 KDM1A KRT15 LCA5L MYOG NOD2 NUP62 OGT SMARCD1 SNAPIN TFIP11 TPM3 UBC WASHC3	60 interacting genes: ACTA1 ACTB BLOC1S6 C1orf216 CAVIN3 CCDC102B CCDC146 CCHCR1 CHRM3 CNN1 DVL2 FAM9C FBXO5 FGA FNDC3B HDDC3 HOOK2 HSF2 HSF4 IFIT3 IKBIP ISG15 KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 MAST2 NEK2 NOD2 NUP54 ODAD1 OIP5 PBX3 PHLDB3 S100A2 S100A4 SMAD3 SNAPIN SUMO4 SYCE1 TAB2 TFPT THAP1 THAP7 TLK1 TMOD1 TMOD2 TNNI1 TNNT1 TRAP1 TRIM27 TRIP6 TSKS VPS52 WASH3P WASHC1 XIAP
Entrez ID		121457	7170
HPRD ID		08092	01840
Ensembl ID		ENSG00000166130	ENSG00000143549
Uniprot IDs		Q70UQ0	A0A087WWU8 A0A0S2Z4G4 A0A0S2Z4G8 A0A0S2Z4I4 A0A2R2Y2Q3 B4DQ80 J3KN67 P06753
PDB IDs			6OTN
Enriched GO Terms of Interacting Partners?		PTB Domain Binding Cellular Response To Oxygen-containing Compound Regulation Of Cellular Response To Stress Supramolecular Fiber Organization Acetylcholine Receptor Activator Activity Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Organization Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Developmental Maturation Regulation Of Glycolytic Process Microtubule-based Transport Transport Along Microtubule Amylin Binding Neuron Maturation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Interleukin-1 Beta Production Lipoprotein Particle Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Chromatin Binding Positive Regulation Of Protein Import Positive Regulation Of DNA-templated Transcription Positive Regulation Of Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Stem Cell Population Maintenance Regulation Of Double-strand Break Repair Protein-containing Complex Disassembly Regulation Of DNA Repair Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Positive Regulation Of Late Endosome To Lysosome Transport Hsp90 Protein Binding Hsp70 Protein Binding Spliceosomal Complex Disassembly Detection Of Muramyl Dipeptide Detection Of Peptidoglycan Muramyl Dipeptide Binding	Cytoskeleton Striated Muscle Thin Filament Actin Filament Organization Supramolecular Fiber Organization Tropomyosin Binding Identical Protein Binding BLOC-1 Complex Centriole Arp2/3 Complex-mediated Actin Nucleation Actin Binding Muscle Contraction P38MAPK Cascade Actin Nucleation Protein K63-linked Ubiquitination Pointed-end Actin Filament Capping Regulation Of Actin Cytoskeleton Organization Muscle System Process Organelle Organization Protein Linear Polyubiquitination Phosphatidylinositol 3-kinase Inhibitor Activity Regulation Of Actin Nucleation Transition Between Fast And Slow Fiber Regulation Of Actin Filament Organization Troponin Complex Regulation Of Lysosome Size BORC Complex Regulation Of Actin Filament-based Process Microtubule-based Movement Microtubule-based Process Retrograde Transport, Endosome To Golgi Microvesicle Actin Filament-based Process Cytoskeleton Organization Regulation Of Protein Ubiquitination Actomyosin Structure Organization Regulation Of Skeletal Muscle Adaptation Regulation Of Endosome Size Cytoskeleton-dependent Intracellular Transport Regulation Of Organelle Organization Regulation Of System Process Positive Regulation Of Biomineral Tissue Development Intracellular Transport Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Vesicle Organization Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Side Of Lysosomal Membrane Lysosomal Transport Protein Kinase Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction
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