ADD2 and RPH3A

Number of citations of the paper that reports this interaction (PMID 7999065)
8

Data Source:
HPRD (in vitro)

		ADD2	RPH3A
Gene Name		adducin 2 (beta)	rabphilin 3A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane F-actin Capping Protein Complex Cytoplasmic Membrane-bounded Vesicle	Golgi Apparatus Cytosol Synaptic Vesicle Extrinsic Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane Neuron Projection Protein Complex Synapse
	Molecular Function	Actin Binding Structural Molecule Activity Calmodulin Binding Spectrin Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Zinc Ion Binding Selenium Binding Rab GTPase Binding Protein Complex Binding Phosphate Ion Binding Inositol 1,4,5 Trisphosphate Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Protein Complex Assembly Actin Cytoskeleton Organization Hemopoiesis Positive Regulation Of Protein Binding Barbed-end Actin Filament Capping Actin Filament Bundle Assembly	Intracellular Protein Transport
Pathways
Drugs
Diseases
GWAS			Platelet counts ( 22139419)
Protein-Protein Interactions		8 interactors: ADD1 APP CALM1 FYN PRKACA PRKCD PTPRZ1 RPH3A	10 interactors: ADD2 CASK GCH1 NRXN1 RAB15 RAB27A RAB3A RAB3B RAB8A YWHAH
Entrez ID		119	22895
HPRD ID		00037	15273
Ensembl ID		ENSG00000075340	ENSG00000089169
Uniprot IDs		P35612 Q05DK5	Q9Y2J0
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Coagulation Regulation Of Protein Binding Hemostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Body Fluid Levels Activation Of Phospholipase C Activity Neurotrophin Signaling Pathway Wound Healing Positive Regulation Of Phospholipase C Activity Regulation Of Binding Cell Activation Response To Wounding Regulation Of Protein Kinase Activity Positive Regulation Of Phospholipase Activity Regulation Of Kinase Activity Innate Immune Response Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Regulation Of Platelet Aggregation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Protein Metabolic Process Detection Of Abiotic Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Dephosphorylation Cellular Response To Growth Factor Stimulus Immune Response Regulation Of Phosphorylation Response To Growth Factor Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Defense Response Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Regulation Of Peptidyl-tyrosine Phosphorylation	Rab Protein Signal Transduction Vesicle Docking Involved In Exocytosis Vesicle Docking Membrane Docking Protein Secretion Secretion Regulation Of Exocytosis Vesicle Localization Ras Protein Signal Transduction Secretion By Cell Regulation Of Cellular Localization Positive Regulation Of Regulated Secretory Pathway Regulation Of Secretion Neurotransmitter Secretion Regulation Of Synaptic Transmission Synaptic Vesicle Transport Exocytosis Positive Regulation Of Transport Cellular Protein Localization Regulation Of Vesicle-mediated Transport Regulation Of Neurotransmitter Levels Establishment Of Protein Localization Organelle Localization Neurotransmitter Transport Regulation Of Regulated Secretory Pathway Intracellular Protein Transport Establishment Of Vesicle Localization Synaptic Vesicle Exocytosis Positive Regulation Of Exocytosis Synaptic Transmission Protein Localization Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Establishment Of Organelle Localization Protein Transport Cellular Localization Intracellular Transport Cell-cell Signaling Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Ion Transport Transport Vesicle-mediated Transport Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Secretion Membrane Organization Protein Localization To Membrane Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of Constitutive Secretory Pathway Protein Complex Assembly Involved In Synapse Maturation
Tagcloud ?		2p13 4p16 acceptor adducin alternative alternatively codons comprises conform consensus duplication ets exon exons frame gata intron isoform mapping mzf1 overlapping smallest sp1 spans splice spliced stop termination utr	abeta25 cholinergic deafferentation downregulated dysfunction exocytosis immunoreactivity interacts involve neocortex neuritic neurofibrillary neuron neurotransmitter plaques postmortem postsynaptic presynaptic rab3a rabphilin reductions selectively snare synaptic synaptopathology tangles triggered vesicle
Tagcloud (Difference) ?		2p13 4p16 acceptor adducin alternative alternatively codons comprises conform consensus duplication ets exon exons frame gata intron isoform mapping mzf1 overlapping smallest sp1 spans splice spliced stop termination utr	abeta25 cholinergic deafferentation downregulated dysfunction exocytosis immunoreactivity interacts involve neocortex neuritic neurofibrillary neuron neurotransmitter plaques postmortem postsynaptic presynaptic rab3a rabphilin reductions selectively snare synaptic synaptopathology tangles triggered vesicle
Tagcloud (Intersection) ?