ARIH2 and APOBEC3G

Number of citations of the paper that reports this interaction (PubMedID 31253590)
89

Data Source:
BioGRID (enzymatic study, enzymatic study)

		ARIH2	APOBEC3G
Description		ariadne RBR E3 ubiquitin protein ligase 2	apolipoprotein B mRNA editing enzyme catalytic subunit 3G
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex	P-body Nucleus Cytoplasm Cytosol Apolipoprotein B MRNA Editing Enzyme Complex Ribonucleoprotein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding DCTP Deaminase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Developmental Cell Growth Defense Response To Virus Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion	Positive Regulation Of Defense Response To Virus By Host Immune System Process Transposable Element Silencing Negative Regulation Of Macromolecule Biosynthetic Process Base Conversion Or Substitution Editing Cytidine To Uridine Editing Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Viral Process Defense Response To Virus DNA Cytosine Deamination Antiviral Innate Immune Response Defense Response To Symbiont
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576) Inflammatory bowel disease ( 23128233)
Interacting Genes		57 interacting genes: APOBEC3C APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST DSCAM EEF1A1 EEF1G EIF4E2 EML4 ENSA IL4R KAT5 KCNQ2 MEOX2 NEDD8 OGT PAX6 PHF7 PPP2R1A PTN RBX1 REL RHEB RNF7 RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 USP2-AS1 UTP14A WDR91	8 interacting genes: APOBEC3F APP ARIH2 CUL5 HDAC6 PRKACA PTN RNF7
Entrez ID		10425	60489
HPRD ID		09286	06172
Ensembl ID		ENSG00000177479	ENSG00000239713
Uniprot IDs		O95376 Q53ET9 Q6IBL8	Q9HC16
PDB IDs		7OD1 7ONI	2JYW 2KBO 2KEM 3E1U 3IQS 3IR2 3V4J 3V4K 4ROV 4ROW 5ZVA 5ZVB 6BUX 6BWY 6K3J 6K3K 7UXD 8CX0 8CX1 8CX2 8H0I 8J62
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Protein Monoubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Cytosol Transferase Activity Macromolecule Metabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Metabolic Process Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Proteolysis TOR Signaling Catabolic Process Protein Neddylation ISG15-protein Conjugation DNA Cytosine Deamination TORC1 Signaling Nucleoplasm Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Cytidine To Uridine Editing Cytidine Deaminase Activity DNA Deamination Negative Regulation Of Neuroblast Proliferation Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Neuroblast Proliferation Regulation Of Neural Precursor Cell Proliferation Regulation Of Post-translational Protein Modification Base Conversion Or Substitution Editing Negative Regulation Of Gene Expression Regulation Of TORC1 Signaling Cellular Response To Nutrient Levels Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination UBC13-MMS2 Complex Regulation Of Protein Metabolic Process Ubiquitin-like Protein Transferase Activity Ubiquitin Ligase Complex	Cul5-RING Ubiquitin Ligase Complex Positive Regulation Of Cellular Component Organization Response To Stress Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Focal Adhesion Disassembly Positive Regulation Of Locomotion Regulation Of Cell Junction Assembly Innate Immune Response Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Defense Response To Virus Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Developmental Growth Developmental Cell Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Virus Response To Parathyroid Hormone Growth Hormone Receptor Signaling Pathway Via JAK-STAT Collateral Sprouting Regulation Of Cell Migration Layer Formation In Cerebral Cortex Negative Regulation Of Focal Adhesion Assembly Response To Auditory Stimulus Regulation Of Cell Motility Immune System Process Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Modulation Of Chemical Synaptic Transmission Regulation Of Locomotion Regulation Of Establishment Of Protein Localization Cell Surface Receptor Signaling Pathway Molecular Function Activator Activity Response To Other Organism Growth Hormone Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Proteolysis CGAS/STING Signaling Pathway Immune Response Positive Regulation Of Focal Adhesion Assembly Regulation Of Chemotaxis
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